DDR
Generic Name
Dexlansoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ddr 60 mg capsule | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
DDR 60 mg capsule contains Dexlansoprazole, a proton pump inhibitor (PPI) used to treat acid-related disorders of the stomach and esophagus, such as gastroesophageal reflux disease (GERD) and erosive esophagitis.
Uses & Indications
Dosage
Adults
Healing of EE: 60 mg once daily for up to 8 weeks. Maintenance of EE: 30 mg or 60 mg once daily for up to 6 months. Symptomatic GERD: 30 mg once daily for 4 weeks.
Elderly
No dosage adjustment necessary based on age.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. No data for severe impairment.
How to Take
Take orally once daily, with or without food. Swallow the capsule whole. Do not chew or crush. For patients who have difficulty swallowing, the capsule can be opened and the granules mixed with applesauce.
Mechanism of Action
Dexlansoprazole inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell. This leads to a dose-dependent inhibition of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Within hours, full effect within a few days.
Excretion
Primarily excreted in urine (approx. 51%) and feces (approx. 47%) as metabolites.
Half life
Approximately 1-2 hours.
Absorption
Well absorbed after oral administration. Peak plasma concentration achieved in 1-2 hours (first release) and 4-5 hours (second release).
Metabolism
Extensively metabolized in the liver by cytochrome P450 (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation
- Concurrent use with rilpivirine-containing products
Drug Interactions
Warfarin
Monitor INR; potential for increased bleeding risk.
Tacrolimus
Increased systemic exposure of tacrolimus has been reported; monitor tacrolimus concentrations.
Clopidogrel
Potential for reduced efficacy of clopidogrel; consider alternative antiplatelet therapy or PPI.
Methotrexate
May increase methotrexate levels, especially in high-dose therapy; consider temporary PPI withdrawal.
Drugs dependent on gastric pH for absorption (e.g., ketoconazole, ampicillin esters, iron salts)
May reduce absorption.
Storage
Store at room temperature (below 30°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally minimal and similar to known adverse events. Management is symptomatic and supportive. Dexlansoprazole is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution advised during breastfeeding; it is unknown if dexlansoprazole is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months, refer to package insert.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in healing erosive esophagitis, maintaining healing, and treating symptomatic GERD.
Lab Monitoring
- Magnesium levels (for long-term use)
- Vitamin B12 levels (for long-term use)
- Liver function tests (in patients with severe hepatic impairment)
Doctor Notes
- Consider lowest effective dose for shortest duration for GERD symptom control.
- Regularly assess the need for continued PPI therapy.
- Be aware of potential drug interactions, especially with warfarin, methotrexate, and clopidogrel.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not take two doses at once.
Driving Precautions
Dexlansoprazole is unlikely to affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair your concentration, avoid these activities.
Lifestyle Advice
- Avoid trigger foods that worsen acid reflux (e.g., spicy, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.