Decomit-Plus
Generic Name
Fluticasone Propionate + Salmeterol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| decomit plus 100 mcg inhaler | ৳ 450.00 | N/A |
Description
Overview of the medicine
Decomit-Plus 100 mcg Inhaler is a combination medicine containing fluticasone propionate, a corticosteroid, and salmeterol, a long-acting beta2-agonist. It is used to prevent and control the symptoms of asthma and chronic obstructive pulmonary disease (COPD).
Uses & Indications
Dosage
Adults
1 inhalation (100 mcg Fluticasone/50 mcg Salmeterol) twice daily, morning and evening.
Elderly
No dosage adjustment generally required, but monitor for side effects.
Renal_impairment
No dosage adjustment required.
How to Take
For oral inhalation only. Shake the inhaler well before each use. Rinse mouth with water and spit out after each use to prevent oral candidiasis.
Mechanism of Action
Fluticasone propionate is a potent corticosteroid with anti-inflammatory action. Salmeterol is a long-acting selective beta2-adrenergic receptor agonist that relaxes bronchial smooth muscle. Together, they reduce inflammation and open airways.
Pharmacokinetics
Onset
Salmeterol: 10-20 minutes for bronchodilation. Fluticasone: Effects develop over days to weeks.
Excretion
Fluticasone: Primarily via feces. Salmeterol: Primarily via feces, some via urine.
Half life
Salmeterol: Approximately 5.5 hours. Fluticasone: Systemic half-life around 8 hours.
Absorption
Fluticasone: Low systemic absorption from inhalation. Salmeterol: Systemic absorption occurs but is minimal.
Metabolism
Fluticasone: Extensively metabolized by CYP3A4. Salmeterol: Extensively metabolized via hydroxylation by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to fluticasone, salmeterol, or any excipients
- Primary treatment of status asthmaticus or acute episodes of asthma/COPD requiring intensive measures
Drug Interactions
Diuretics
May exacerbate hypokalemia when used with high doses of beta-agonists.
Beta-blockers
May block the bronchodilatory effect of salmeterol, especially non-selective beta-blockers.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase systemic exposure to fluticasone and salmeterol, leading to increased risk of systemic corticosteroid effects and cardiovascular adverse effects.
Storage
Store below 30°C. Do not freeze. Protect from direct sunlight and heat. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremor, hypertension (salmeterol) or Cushingoid features (fluticasone). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to fluticasone, salmeterol, or any excipients
- Primary treatment of status asthmaticus or acute episodes of asthma/COPD requiring intensive measures
Drug Interactions
Diuretics
May exacerbate hypokalemia when used with high doses of beta-agonists.
Beta-blockers
May block the bronchodilatory effect of salmeterol, especially non-selective beta-blockers.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase systemic exposure to fluticasone and salmeterol, leading to increased risk of systemic corticosteroid effects and cardiovascular adverse effects.
Storage
Store below 30°C. Do not freeze. Protect from direct sunlight and heat. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremor, hypertension (salmeterol) or Cushingoid features (fluticasone). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from manufacturing date, or as indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired for original combination, generics available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for both asthma and COPD, demonstrating significant efficacy in improving lung function, reducing symptoms, and decreasing the frequency of exacerbations compared to monotherapy.
Lab Monitoring
- Regular monitoring of lung function (e.g., FEV1, PEF)
- Monitor for signs of adrenal suppression if high doses used for prolonged periods
- Potassium levels (in some cases)
Doctor Notes
- Emphasize proper inhaler technique to ensure optimal drug delivery and minimize local side effects.
- Counsel patients on the crucial difference between this maintenance inhaler and a rapid-acting rescue inhaler.
- Monitor patients for potential systemic corticosteroid effects, especially with high doses or in susceptible individuals.
- Regularly assess lung function and adjust therapy as needed.
Patient Guidelines
- Always use exactly as prescribed by your doctor.
- Do not stop using without consulting your doctor.
- Seek medical attention for worsening symptoms or acute attacks (this inhaler is not for rescue).
- Regularly rinse your mouth with water and spit out after use to prevent oral candidiasis.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally no effect on driving, but if dizziness or blurred vision occurs, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Maintain good hydration.
- Follow a healthy diet and engage in regular, moderate exercise as tolerated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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