Deen
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deen 5 mg tablet | ৳ 2.51 | N/A |
Description
Overview of the medicine
Desloratadine is a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
5 mg once daily, with or without food.
Elderly
No dosage adjustment generally required, but caution with renal/hepatic impairment.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), 5 mg every other day is recommended.
How to Take
Take orally, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It inhibits the release of histamine from mast cells and blocks histamine-induced effects.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal or hepatic impairment without dose adjustment.
Drug Interactions
Cimetidine
May increase desloratadine plasma concentrations.
Erythromycin
May increase desloratadine plasma concentrations.
Ketoconazole
May increase desloratadine plasma concentrations.
Storage
Store in a cool and dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence. Management is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal or hepatic impairment without dose adjustment.
Drug Interactions
Cimetidine
May increase desloratadine plasma concentrations.
Erythromycin
May increase desloratadine plasma concentrations.
Ketoconazole
May increase desloratadine plasma concentrations.
Storage
Store in a cool and dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence. Management is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus/infant. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved by health authorities
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.
Lab Monitoring
- No routine lab monitoring is generally required. Liver function tests may be considered in patients with pre-existing hepatic impairment or those developing symptoms suggestive of liver dysfunction.
Doctor Notes
- Advise patients that desloratadine is typically non-sedating, but counsel on potential individual variations in response.
- Consider dosage adjustment for patients with severe renal or hepatic impairment.
- Monitor for hypersensitivity reactions, although rare.
Patient Guidelines
- Do not exceed the recommended dose.
- Report any unusual side effects to your doctor.
- Keep out of reach of children.
- Store at room temperature and protect from light and moisture.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally non-sedating, but caution advised until individual response is known, as some individuals may experience drowsiness.
Lifestyle Advice
- Avoid known allergens or triggers for your allergic symptoms.
- Maintain a clean environment to reduce exposure to dust mites and pollen.
- Consult your doctor for personalized lifestyle advice.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.