Deferonil
Generic Name
Deferox
Manufacturer
Globex Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Deferox is an oral iron chelating agent used for the treatment of chronic iron overload, particularly in patients with transfusion-dependent anemias.
Uses & Indications
Dosage
Adults
Typically 10-30 mg/kg orally once daily, adjusted based on iron burden.
Elderly
Start with lower doses and monitor closely for adverse effects.
Renal_impairment
Dose reduction required; contraindicated in severe renal impairment.
How to Take
Take orally once daily, preferably with a light meal at the same time each day.
Mechanism of Action
Deferox binds to ferric iron (Fe3+) in a 2:1 ratio to form a stable complex, which is then excreted, primarily via bile. This reduces systemic iron levels.
Pharmacokinetics
Onset
Iron chelation activity begins within hours.
Excretion
Mainly through bile/feces and to a lesser extent via urine.
Half life
Approximately 5-10 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability is moderate.
Metabolism
Extensively metabolized, primarily by glucuronidation.
Side Effects
Contraindications
- •Known hypersensitivity to Deferox or any excipients.
- •Severe renal impairment (creatinine clearance < 10 mL/min).
- •Myelodysplastic syndromes with low bone marrow iron.
Drug Interactions
Vitamin C
Co-administration with high doses of Vitamin C may increase iron toxicity, especially in patients with severe cardiac iron overload. Avoid doses >200 mg/day of Vitamin C.
Antacids (aluminum-containing)
May reduce Deferox absorption. Take at least 2 hours apart.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include gastrointestinal disturbances, headache, dizziness, and visual/auditory disturbances. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding due to lack of data on excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Generic Available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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