Deflox
Generic Name
Deflazacort
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflox 250 mg tablet | ৳ 10.50 | ৳ 105.00 |
Description
Overview of the medicine
Deflox 250 mg Tablet contains Deflazacort, a corticosteroid used to treat various inflammatory and autoimmune conditions. It works by reducing inflammation and suppressing the immune system. Note: 250 mg is a very high strength for Deflazacort and usually prescribed for specific severe conditions under strict medical supervision.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition. Typically, Deflazacort dosage for adults ranges from 6 mg to 90 mg daily. The 250 mg strength would be considered a very high dose, used only under strict medical supervision for specific severe conditions, or as a loading dose.
Elderly
No specific dose adjustment is usually required, but caution is advised, and lower doses may be considered due to increased sensitivity to side effects.
Renal_impairment
No specific dose adjustment is generally required, but monitoring is recommended.
How to Take
Take orally, preferably with or after food to minimize gastrointestinal upset. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Deflazacort is a glucocorticoid, which acts by binding to specific intracellular glucocorticoid receptors. This complex then translocates to the nucleus, where it modulates gene expression, leading to anti-inflammatory and immunosuppressive effects. It inhibits the release of various inflammatory mediators and alters the function of immune cells.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within a few hours to a day.
Excretion
Primarily excreted in the urine (approximately 70%) and feces (approximately 30%), mainly as inactive metabolites.
Half life
The active metabolite has a plasma half-life of approximately 1.5-2 hours, but its biological half-life is longer (11-36 hours).
Absorption
Rapidly absorbed after oral administration and converted to its active metabolite, 21-desacetyl deflazacort. Peak plasma concentrations are reached within 1.5-2 hours.
Metabolism
Extensively metabolized in the liver to the active metabolite 21-desacetyl deflazacort, followed by further metabolism.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effect; close monitoring of INR is needed.
Ketoconazole and other CYP3A4 inhibitors
May increase Deflazacort plasma concentrations, requiring dose adjustment.
Diuretics (e.g., Thiazides, Loop diuretics)
May enhance potassium depletion.
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Increased risk of gastrointestinal ulceration.
Phenytoin, Rifampin, Carbamazepine (CYP3A4 inducers)
May decrease Deflazacort efficacy, requiring dose adjustment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include exaggeration of known side effects. Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose is suspected. Seek immediate medical attention.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Corticosteroids are excreted in breast milk; caution is advised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effect; close monitoring of INR is needed.
Ketoconazole and other CYP3A4 inhibitors
May increase Deflazacort plasma concentrations, requiring dose adjustment.
Diuretics (e.g., Thiazides, Loop diuretics)
May enhance potassium depletion.
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Increased risk of gastrointestinal ulceration.
Phenytoin, Rifampin, Carbamazepine (CYP3A4 inducers)
May decrease Deflazacort efficacy, requiring dose adjustment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include exaggeration of known side effects. Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose is suspected. Seek immediate medical attention.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Corticosteroids are excreted in breast milk; caution is advised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
Clinical trials for Deflazacort have demonstrated its efficacy in various inflammatory and autoimmune conditions, particularly highlighting its benefits in Duchenne Muscular Dystrophy and its relatively lower impact on bone mineral density compared to other glucocorticoids. Studies also focus on long-term safety and efficacy profiles.
Lab Monitoring
- Blood pressure
- Blood glucose levels
- Electrolytes (especially potassium)
- Bone mineral density (with long-term use)
- Ophthalmologic examination (for glaucoma/cataracts)
- Growth in children
Doctor Notes
- Emphasize gradual tapering to prevent adrenal crisis.
- Monitor blood sugar, blood pressure, and bone density regularly.
- Counsel patients on infection prevention strategies, especially for immunocompromised individuals.
- Consider calcium and vitamin D supplementation, particularly for long-term users.
- Educate on potential psychological effects.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor.
- Inform your doctor about any new or worsening symptoms.
- Avoid contact with people who have infections (e.g., chickenpox, measles).
- Take with food to reduce stomach upset.
- Carry a steroid warning card.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Deflox 250 mg Tablet may cause dizziness, visual disturbances or muscle weakness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise to maintain bone health.
- Avoid excessive alcohol consumption.
- Monitor for signs of infection and report promptly.
- Maintain good hygiene.
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