Deformin
Generic Name
Metformin 850 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deformin 850 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Deformin 850 mg Tablet contains Metformin, an oral antidiabetic medicine used to treat type 2 diabetes mellitus. It helps to control high blood sugar levels by decreasing glucose production in the liver, decreasing glucose absorption from the intestines, and improving insulin sensitivity.
Uses & Indications
Dosage
Adults
Initial dose is typically 500 mg or 850 mg once or twice daily with meals. Dosage can be gradually increased to a maximum of 2550 mg daily, divided into 2-3 doses. For Deformin 850 mg, a common starting dose is 850 mg once daily, or 850 mg twice daily with morning and evening meals.
Elderly
A lower initial dose and careful monitoring of renal function are recommended due to the potential for decreased renal function in the elderly. Dosage adjustments should be based on renal function.
Renal_impairment
Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In moderate impairment (eGFR 30-45 mL/min/1.73 m²), dose reduction or discontinuation may be necessary with close monitoring.
How to Take
Take Deformin 850 mg Tablet orally with or after meals to reduce gastrointestinal side effects. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Metformin reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. It also delays intestinal glucose absorption and increases peripheral glucose uptake and utilization by improving insulin sensitivity. It does not stimulate insulin secretion and therefore does not cause hypoglycemia when used alone.
Pharmacokinetics
Onset
Onset of glucose-lowering effect is gradual, typically observed within days to weeks.
Excretion
Excreted primarily by the kidneys via glomerular filtration and tubular secretion. Approximately 90% of the absorbed drug is eliminated via the renal route within 24 hours.
Half life
Plasma elimination half-life is approximately 6.2 hours. In whole blood, the half-life is approximately 17.6 hours.
Absorption
Oral bioavailability is approximately 50-60%. Food delays and slightly decreases the extent of absorption.
Metabolism
Metformin is not metabolized in the liver. It is excreted unchanged.
Side Effects
Contraindications
- Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis
- Hypersensitivity to metformin or any component of the formulation
- Acute or chronic disease that may cause tissue hypoxia (e.g., cardiac failure, respiratory failure, recent myocardial infarction, shock)
- Severe hepatic impairment
Drug Interactions
Cimetidine
May increase metformin plasma concentration, increasing risk of lactic acidosis.
Iodinated Contrast Agents
Temporarily discontinue metformin at the time of or prior to iodinated contrast imaging procedures in patients with an eGFR between 30 and 60 mL/min/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure, and restart metformin if renal function is stable.
Diuretics (e.g., Thiazides, Loop Diuretics)
May affect renal function, potentially increasing metformin levels.
Carbonic Anhydrase Inhibitors (e.g., Topiramate, Acetazolamide)
May increase the risk of lactic acidosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin can lead to lactic acidosis, characterized by symptoms like malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Management involves discontinuing metformin, instituting general supportive measures, and prompt hemodialysis to correct the acidosis and remove accumulated metformin.
Pregnancy & Lactation
Pregnancy Category B. While studies in animals have not shown risk, adequate and well-controlled studies in pregnant women are lacking. Metformin may be considered if benefits outweigh risks, often switching to insulin during pregnancy. Metformin is excreted into breast milk; however, the amount is usually low and unlikely to cause harm to a breastfed infant. Consult a doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis
- Hypersensitivity to metformin or any component of the formulation
- Acute or chronic disease that may cause tissue hypoxia (e.g., cardiac failure, respiratory failure, recent myocardial infarction, shock)
- Severe hepatic impairment
Drug Interactions
Cimetidine
May increase metformin plasma concentration, increasing risk of lactic acidosis.
Iodinated Contrast Agents
Temporarily discontinue metformin at the time of or prior to iodinated contrast imaging procedures in patients with an eGFR between 30 and 60 mL/min/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure, and restart metformin if renal function is stable.
Diuretics (e.g., Thiazides, Loop Diuretics)
May affect renal function, potentially increasing metformin levels.
Carbonic Anhydrase Inhibitors (e.g., Topiramate, Acetazolamide)
May increase the risk of lactic acidosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin can lead to lactic acidosis, characterized by symptoms like malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Management involves discontinuing metformin, instituting general supportive measures, and prompt hemodialysis to correct the acidosis and remove accumulated metformin.
Pregnancy & Lactation
Pregnancy Category B. While studies in animals have not shown risk, adequate and well-controlled studies in pregnant women are lacking. Metformin may be considered if benefits outweigh risks, often switching to insulin during pregnancy. Metformin is excreted into breast milk; however, the amount is usually low and unlikely to cause harm to a breastfed infant. Consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific details on packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Metformin has been extensively studied in numerous clinical trials establishing its efficacy and safety in managing type 2 diabetes. Ongoing research continues to explore its potential benefits in other conditions like cancer prevention and anti-aging.
Lab Monitoring
- Renal function (eGFR) at baseline and at least annually
- Blood glucose levels (fasting, postprandial)
- HbA1c levels (every 3-6 months)
- Vitamin B12 levels (especially with long-term use or symptoms of deficiency)
Doctor Notes
- Assess renal function (eGFR) prior to initiation and periodically thereafter.
- Educate patients on symptoms of lactic acidosis and B12 deficiency.
- Consider temporary discontinuation in patients undergoing imaging procedures with iodinated contrast or surgery.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor.
- Follow a healthy diet and engage in regular physical activity as advised by your healthcare provider.
- Report any unusual symptoms, especially severe nausea, vomiting, abdominal pain, or muscle pain, to your doctor immediately.
Missed Dose Advice
If you miss a dose of Deformin, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Deformin 850 mg Tablet alone does not cause hypoglycemia, so it typically does not impair the ability to drive or operate machinery. However, if used in combination with other antidiabetic agents (e.g., sulfonylureas, insulin) that can cause hypoglycemia, patients should be aware of the signs and symptoms of low blood sugar and exercise caution.
Lifestyle Advice
- Maintain a balanced diet, limiting sugar and refined carbohydrates.
- Regular exercise helps improve insulin sensitivity and manage blood sugar.
- Achieve and maintain a healthy weight.
- Limit alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Deformin Brand
Other medicines available under the same brand name
