Defungi
Generic Name
Fluconazole
Manufacturer
Drug International Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| defungi 50 mg capsule | ৳ 8.06 | ৳ 80.60 |
Description
Overview of the medicine
Defungi 50 mg capsule contains Fluconazole, an antifungal agent used to treat various fungal infections, including candidiasis and cryptococcal meningitis.
Uses & Indications
Dosage
Adults
Varies based on infection type and severity. For vaginal candidiasis, a single 150 mg oral dose. For oropharyngeal candidiasis, 50-100 mg once daily for 7-14 days. For systemic infections, 400 mg on day 1 followed by 200-400 mg once daily.
Elderly
Dosage adjustment not usually required unless renal function is impaired.
Renal_impairment
Dosage adjustment required. For creatinine clearance <50 mL/min, reduce dose by 50%.
How to Take
Capsules can be taken with or without food. Swallow whole with water.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450-dependent 14-alpha-demethylase, which is essential for ergosterol biosynthesis. This inhibition leads to the accumulation of 14-alpha-methyl sterols and a decrease in ergosterol, disrupting fungal cell membrane integrity.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 1-2 hours.
Excretion
Primarily renal excretion (approximately 80% as unchanged drug).
Half life
Approximately 30 hours.
Absorption
Well absorbed orally, bioavailability >90%.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Fluconazole or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin
Drug Interactions
Warfarin
Increased prothrombin time.
Phenytoin
Increased phenytoin levels.
Amiodarone
Increased risk of QT prolongation.
Rifampicin
Decreased fluconazole levels.
Hydrochlorothiazide
Increased fluconazole levels.
Cyclosporine, Tacrolimus
Increased immunosuppressant levels.
Oral Hypoglycemics (sulfonylureas)
Increased blood glucose lowering effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Treatment involves symptomatic and supportive measures, and gastric lavage if appropriate. Hemodialysis significantly reduces plasma levels.
Pregnancy & Lactation
Avoid during pregnancy unless benefits outweigh risks, especially in the first trimester. Fluconazole is excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Fluconazole or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin
Drug Interactions
Warfarin
Increased prothrombin time.
Phenytoin
Increased phenytoin levels.
Amiodarone
Increased risk of QT prolongation.
Rifampicin
Decreased fluconazole levels.
Hydrochlorothiazide
Increased fluconazole levels.
Cyclosporine, Tacrolimus
Increased immunosuppressant levels.
Oral Hypoglycemics (sulfonylureas)
Increased blood glucose lowering effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hallucinations and paranoid behavior. Treatment involves symptomatic and supportive measures, and gastric lavage if appropriate. Hemodialysis significantly reduces plasma levels.
Pregnancy & Lactation
Avoid during pregnancy unless benefits outweigh risks, especially in the first trimester. Fluconazole is excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Fluconazole for various fungal infections.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in patients with pre-existing liver disease or during prolonged therapy
- Renal function monitoring
- Electrolyte monitoring in patients at risk of arrhythmias
Doctor Notes
- Counsel patients on importance of completing full course.
- Be aware of potential drug interactions, especially with CYP3A4 inhibitors/inducers.
- Monitor liver function in patients on prolonged therapy or with pre-existing hepatic impairment.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Report any severe side effects immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or seizures in some individuals; avoid driving or operating machinery if affected.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Avoid excessive moisture in areas prone to fungal infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.