Delanzo
Generic Name
Dexlansoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| delanzo 60 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Dexlansoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat heartburn, acid reflux, and other symptoms associated with gastroesophageal reflux disease (GERD), and to heal erosive esophagitis.
Uses & Indications
Dosage
Adults
For healing EE: 60 mg once daily for up to 8 weeks. For maintenance of EE: 30 mg or 60 mg once daily. For symptomatic GERD: 30 mg once daily for up to 4 weeks.
Elderly
No dosage adjustment necessary based on age alone, but caution with concomitant diseases and medications.
Renal_impairment
No dosage adjustment required for renal impairment.
How to Take
Swallow the capsule whole. Do not chew or crush. Can be taken with or without food. If unable to swallow, capsule can be opened and contents mixed with applesauce.
Mechanism of Action
Dexlansoprazole is an irreversible proton pump inhibitor that blocks the final step in gastric acid secretion by inhibiting the H+/K+-ATPase enzyme system at the secretory surface of the gastric parietal cell.
Pharmacokinetics
Onset
Within hours
Excretion
Primarily excreted in urine (approximately 50%) and feces (approximately 23%) as metabolites.
Half life
Approximately 1-2 hours
Absorption
Bioavailability is about 47%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation
- Concomitant use with rilpivirine-containing products
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel; consider alternative PPI.
Methotrexate
Increased plasma levels of methotrexate; temporary PPI discontinuation may be needed for high-dose methotrexate.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
No specific antidote. Symptomatic and supportive treatment recommended.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Exercise caution when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA
Patent Status
Patent expired for generic versions
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety for approved indications.
Lab Monitoring
- Monitor INR/prothrombin time in patients on warfarin
- Magnesium levels with prolonged use
Doctor Notes
- Advise patients on potential for increased risk of bone fracture with long-term PPI use.
- Consider vitamin B12 supplementation for prolonged therapy.
- Evaluate patients for C. difficile if diarrhea occurs.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty, acidic foods).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.