Deloxi
Generic Name
Desloratadine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deloxi 20 mg dr capsule | ৳ 7.00 | ৳ 42.00 |
| deloxi 60 mg dr capsule | ৳ 18.00 | ৳ 72.00 |
Description
Overview of the medicine
Deloxi contains Desloratadine, a long-acting tricyclic antihistamine with selective H1-receptor antagonist activity. It is used to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years of age and over: 5 mg once daily.
Elderly
No dosage adjustment generally required for elderly patients.
Renal_impairment
For patients with renal or hepatic impairment, a starting dose of 5 mg every other day is recommended.
How to Take
May be taken with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine is a non-sedating, long-acting antihistamine with potent, selective peripheral H1-receptor antagonist activity. It inhibits the release of histamine from mast cells and basophils, thereby reducing allergic symptoms.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Excreted almost equally in urine and feces.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
- Patients with severe renal impairment.
Drug Interactions
Cimetidine
Increased plasma concentrations of Desloratadine.
Fluoxetine
Increased plasma concentrations of Desloratadine.
Erythromycin
Increased plasma concentrations of Desloratadine.
Ketoconazole
Increased plasma concentrations of Desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, increased heart rate, and headache. In the event of overdose, symptomatic and supportive treatment is recommended. Desloratadine is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies the potential risk to the fetus. Lactation: Desloratadine is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Desloratadine for allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Kidney function tests (in patients with renal impairment)
Doctor Notes
- Advise patients on appropriate use and potential side effects.
- Consider renal/hepatic dose adjustment for impaired patients.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Although Desloratadine is non-sedating, individual responses vary. Patients should be advised to determine their response to the drug before engaging in activities requiring mental alertness, such as driving or operating machinery.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Stay hydrated by drinking plenty of water.
- Avoid alcohol as it may enhance drowsiness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.