Demacrosin
Generic Name
demacro-500-mg-tablet
Manufacturer
Generic Pharma (BD) Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| demacro 500 mg tablet | ৳ 30.00 | N/A |
Description
Overview of the medicine
Demacro-500 mg tablet is a broad-spectrum macrolide antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 3-7 days, depending on the infection severity and type, or as directed by physician.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution is advised in those with pre-existing cardiac conditions or hepatic/renal impairment.
Renal_impairment
No dose adjustment is typically needed for mild to moderate renal impairment. For severe impairment, caution is advised and dose adjustment may be considered.
How to Take
Take the tablet orally with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Demacro-500 mg tablet inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with bacterial growth and replication. It is primarily bacteriostatic.
Pharmacokinetics
Onset
Within 2-3 hours for symptomatic relief in acute infections.
Excretion
Mainly excreted unchanged in bile; a small portion is excreted via urine.
Half life
Approximately 12-24 hours, allowing for once-daily dosing in many cases.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability can be affected by food (may increase or decrease depending on the specific macrolide).
Metabolism
Primarily hepatic, metabolized by CYP450 enzymes (though some macrolides like azithromycin have minimal CYP interaction).
Side Effects
Contraindications
- •Hypersensitivity to Demacro, other macrolide antibiotics, or any component of the formulation.
- •History of cholestatic jaundice/hepatic dysfunction associated with prior use of Demacro or other macrolides.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased anticoagulant effect, monitor INR.
Ergot alkaloids (e.g., ergotamine)
Potentiation of ergot toxicity.
Antacids containing aluminum or magnesium
May decrease absorption if taken concurrently.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and abdominal discomfort. Treatment is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B/C (depending on specific macrolide). Consult a doctor before use during pregnancy or lactation. Excreted into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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