Dementa-XR
Generic Name
Galantamine Extended-Release Capsule
Manufacturer
Unspecified Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dementa xr 7 mg capsule | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Galantamine Extended-Release (XR) capsule is an acetylcholinesterase inhibitor used for the symptomatic treatment of mild to moderate dementia of the Alzheimer's type. The XR formulation allows for once-daily dosing.
Uses & Indications
Dosage
Adults
Initial: 8 mg once daily for 4 weeks. Maintenance: Increase to 16 mg once daily for at least 4 weeks. Max: 24 mg once daily if tolerated.
Elderly
Same as adults, but individualize dosage and monitor for adverse effects.
Renal_impairment
Moderate impairment (CrCl 9-59 mL/min): Max 16 mg/day. Severe impairment (CrCl < 9 mL/min): Not recommended.
How to Take
Take orally once daily, preferably with breakfast. Swallow the capsule whole with water; do not chew, crush, or open.
Mechanism of Action
Galantamine selectively inhibits acetylcholinesterase, leading to an increase in acetylcholine concentration in the brain, thereby enhancing cholinergic function. It also modulates nicotinic acetylcholine receptors, further contributing to its therapeutic effects.
Pharmacokinetics
Onset
Symptomatic improvement typically observed after several weeks of continuous treatment.
Excretion
Excreted predominantly by the kidneys, with a significant portion as unchanged drug and metabolites.
Half life
Approximately 7-8 hours for galantamine.
Absorption
Well absorbed from the gastrointestinal tract; absolute bioavailability is approximately 90%. Peak plasma concentrations are reached within 5 hours for the extended-release formulation.
Metabolism
Primarily hepatic metabolism via cytochrome P450 enzymes (CYP2D6 and CYP3A4).
Side Effects
Contraindications
- •Hypersensitivity to galantamine hydrobromide or any excipients.
- •Severe hepatic impairment.
- •Severe renal impairment (CrCl < 9 mL/min).
Drug Interactions
Anticholinergics (e.g., atropine)
May antagonize the effects of galantamine.
Cholinomimetics (e.g., bethanechol)
May have additive effects, increasing risk of cholinergic side effects.
Neuromuscular blockers (e.g., succinylcholine)
May potentiate the neuromuscular blocking effects.
Paroxetine, Quinidine, Ketoconazole, Ritonavir
May increase galantamine exposure due to inhibition of CYP2D6 or CYP3A4.
Storage
Store at room temperature (20-25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, gastrointestinal cramping, bradycardia, hypotension, syncope, seizures, severe muscle weakness, and respiratory depression. Treatment is supportive; atropine can be used for significant bradycardia or cholinergic crisis.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to lack of data on excretion in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent Expired
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Global Brand Names
International brand names for this medicine
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