Demobet
Generic Name
Clobetasol Propionate
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| demobet 005 cream | ৳ 70.00 | N/A |
| demobet 005 ointment | ৳ 75.00 | N/A |
Description
Overview of the medicine
Demobet Cream contains Clobetasol Propionate, a highly potent topical corticosteroid used to reduce inflammation and itching associated with skin conditions like eczema, psoriasis, and dermatitis.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily for up to 2 weeks. Do not use for more than 2 weeks without re-evaluation.
Elderly
Use with caution. Dosage adjustments may be necessary due to potential skin fragility and increased systemic absorption.
Renal_impairment
No specific dosage adjustments required for topical use, but systemic absorption could be a concern with severe impairment.
How to Take
For topical use only. Apply a thin layer to the affected area and gently rub in. Wash hands before and after application.
Mechanism of Action
Clobetasol Propionate acts by inducing phospholipase A2 inhibitory proteins, lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Onset
Rapid onset of anti-inflammatory effects, usually within hours to days.
Excretion
Metabolites excreted primarily in urine, some in bile.
Half life
Not specifically well-defined for topical use, but systemic half-life of corticosteroids generally range from 18-36 hours.
Absorption
Significant absorption can occur through the skin, especially with prolonged use, occlusive dressings, or on compromised skin. Systemic absorption varies based on area and integrity of skin.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or any components of the formulation.
- Rosacea, acne vulgaris, perioral dermatitis, pruritus without inflammation.
- Bacterial, fungal, viral, or parasitic infections of the skin (without concomitant anti-infective therapy).
Drug Interactions
CYP3A4 inhibitors (e.g., Ritonavir, Itraconazole)
Systemic exposure to clobetasol may be increased, potentially leading to systemic corticosteroid effects. Use with caution.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze.
Overdose
Acute overdose is unlikely. Chronic overuse or misuse can lead to systemic corticosteroid effects like Cushing's syndrome, hyperglycemia, or HPA axis suppression.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Use with caution during lactation; avoid application on breast area.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Many clinical trials exist supporting its efficacy and safety for specific indications.
Lab Monitoring
- Monitor for signs of HPA axis suppression (e.g., cortisol levels) with extensive or prolonged use.
Doctor Notes
- Potent corticosteroid; use for shortest duration possible to achieve control.
- Advise patients on proper application technique and warning signs of side effects.
Patient Guidelines
- Use only as directed by a physician.
- Do not use on the face, groin, or axillae unless directed by a doctor.
- Do not cover the treated area with occlusive dressings unless instructed.
- Limit use to 2 weeks for adults and 5 days for children, generally.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Driving Precautions
Demobet is a topical preparation and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Avoid irritants that can worsen skin conditions.
- Maintain good skin hygiene.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.