Denamine
Generic Name
Chlorpheniramine Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| denamine 4 mg tablet | ৳ 0.16 | ৳ 1.60 |
Description
Overview of the medicine
Denamine 4 mg Tablet is an antihistamine used to relieve symptoms of allergic reactions such as sneezing, runny nose, watery eyes, and itching. It works by blocking the action of histamine, a natural substance that causes allergic symptoms.
Uses & Indications
Dosage
Adults
4 mg every 4-6 hours, not exceeding 24 mg in 24 hours.
Elderly
Lower doses may be required (e.g., 2 mg every 4-6 hours) due to increased sensitivity and risk of side effects.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment.
How to Take
Take orally with or without food. Swallow the tablet whole with water.
Mechanism of Action
Chlorpheniramine Maleate acts as a competitive antagonist of histamine at H1 receptors, thereby preventing the actions of histamine, such as vasodilation, increased capillary permeability, and spasm of smooth muscle.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in urine as metabolites and some unchanged drug.
Half life
12-43 hours (highly variable)
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-6 hours.
Metabolism
Extensively metabolized in the liver by demethylation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to chlorpheniramine or any component of the formulation.
- Acute asthma attacks.
- Newborns or premature infants.
- Concomitant use with MAO inhibitors.
Drug Interactions
Monoamine Oxidase Inhibitors (MAOIs)
Prolongation and intensification of anticholinergic effects and CNS depression.
Anticholinergic Drugs (e.g., tricyclic antidepressants)
Additive anticholinergic effects (dry mouth, blurred vision, urinary retention).
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased sedative effect.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, CNS depression or stimulation (especially in children), dry mouth, flushed skin, dilated pupils, fever, and gastrointestinal symptoms. Severe overdose can lead to convulsions, coma, and respiratory depression. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk and cause drowsiness in the infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to chlorpheniramine or any component of the formulation.
- Acute asthma attacks.
- Newborns or premature infants.
- Concomitant use with MAO inhibitors.
Drug Interactions
Monoamine Oxidase Inhibitors (MAOIs)
Prolongation and intensification of anticholinergic effects and CNS depression.
Anticholinergic Drugs (e.g., tricyclic antidepressants)
Additive anticholinergic effects (dry mouth, blurred vision, urinary retention).
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased sedative effect.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, CNS depression or stimulation (especially in children), dry mouth, flushed skin, dilated pupils, fever, and gastrointestinal symptoms. Severe overdose can lead to convulsions, coma, and respiratory depression. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk and cause drowsiness in the infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Chlorpheniramine has been extensively studied since its introduction and its efficacy in treating allergic conditions is well-established through numerous clinical trials and widespread clinical use.
Lab Monitoring
- No routine lab monitoring is generally required for therapeutic use. In cases of suspected toxicity or long-term high-dose therapy, blood counts may be considered.
Doctor Notes
- Advise patients about potential sedation and to avoid activities requiring mental alertness.
- Caution in patients with narrow-angle glaucoma, prostatic hypertrophy, bladder neck obstruction, or pyloroduodenal obstruction due to anticholinergic effects.
- Monitor for paradoxical excitation in children and elderly.
Patient Guidelines
- Avoid driving or operating heavy machinery if you experience drowsiness or dizziness.
- Avoid alcohol consumption while taking this medication, as it can increase sedative effects.
- Do not exceed the recommended dose without consulting a doctor.
- Consult your doctor if symptoms persist for more than 7 days or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Denamine may cause drowsiness or dizziness, which can impair your ability to drive or operate machinery. Exercise caution and avoid such activities if affected.
Lifestyle Advice
- Identify and avoid known allergens (e.g., pollen, dust mites, pet dander) to minimize exposure.
- Maintain good indoor air quality and hygiene to reduce irritants.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.