Deon
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deon 200000 iu injectable solution oral im | ৳ 90.00 | N/A |
Description
Overview of the medicine
Deon 200,000 IU is a high-dose Cholecalciferol (Vitamin D3) solution used to treat and prevent severe Vitamin D deficiency. It can be administered orally or via intramuscular injection.
Uses & Indications
Dosage
Adults
For severe deficiency: Typically 200,000 IU as a single oral or intramuscular dose, repeated after 1-3 months if necessary, or as directed by a physician.
Elderly
Similar to adult dosage, but caution advised due to potential for comorbidities and polypharmacy. Monitor calcium levels closely.
Renal_impairment
Use with caution. Monitoring of calcium and phosphate levels is essential. May require dose adjustment.
How to Take
For oral use, the solution can be swallowed directly or mixed with a small amount of food or drink. For intramuscular use, it should be administered by a healthcare professional deep into the muscle. Do not inject intravenously.
Mechanism of Action
Cholecalciferol is converted in the liver to 25-hydroxyvitamin D3 and then in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol), the active form of Vitamin D. Calcitriol regulates calcium and phosphate homeostasis, promoting their absorption from the gut and regulating bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects may take days to weeks to manifest, as circulating 25(OH)D levels need to normalize.
Excretion
Mainly excreted in bile and feces, with a small percentage excreted renally.
Half life
The half-life of cholecalciferol is approximately 19-25 hours, but the active metabolite 25(OH)D has a half-life of about 2-3 weeks due to storage in adipose tissue.
Absorption
Rapidly absorbed from the gastrointestinal tract (oral) or injection site (intramuscular). Absorption is enhanced in the presence of dietary fat.
Metabolism
Primarily hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol), then in the kidneys to the active metabolite 1,25-dihydroxyvitamin D3 (calcitriol).
Side Effects
Contraindications
- •Hypercalcemia (high blood calcium levels)
- •Hypervitaminosis D (Vitamin D toxicity)
- •Hypersensitivity to Cholecalciferol or any excipients
- •Nephrolithiasis (kidney stones) in patients with hypercalcemia
- •Severe renal impairment (unless carefully monitored)
Drug Interactions
Corticosteroids
May antagonize the effects of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Cardiac glycosides (e.g., digoxin)
Hypercalcemia induced by Vitamin D may potentiate the effects of cardiac glycosides, leading to toxicity.
Orlistat, Cholestyramine, Mineral oil
May impair absorption of Vitamin D.
Anticonvulsants (e.g., phenytoin, barbiturates)
May increase the metabolism of Vitamin D, reducing its effectiveness.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose (hypervitaminosis D) are primarily due to hypercalcemia and include nausea, vomiting, loss of appetite, thirst, polyuria, constipation, weakness, fatigue, confusion, and in severe cases, kidney damage or cardiac arrhythmias. Management involves discontinuing the product, hydration, a low-calcium diet, and in severe cases, corticosteroids or calcitonin.
Pregnancy & Lactation
Vitamin D is essential during pregnancy and lactation. However, high doses should be avoided as excessive Vitamin D can be harmful to the fetus or infant. Use only under medical supervision when benefits outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on manufacturer specifications. Check expiry date on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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