Deotrim
Generic Name
Co-trimoxazole (Sulfamethoxazole 400 mg + Trimethoprim 80 mg)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deotrim 400 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Deotrim 400 mg Tablet is a combination antibiotic containing Sulfamethoxazole and Trimethoprim. It is used to treat various bacterial infections, including urinary tract infections, respiratory tract infections, gastrointestinal infections, and certain types of pneumonia.
Uses & Indications
Dosage
Adults
Typically, two tablets (Sulfamethoxazole 400 mg + Trimethoprim 80 mg) twice daily for 7-14 days.
Elderly
Dosage adjustment may be required based on renal function.
Renal_impairment
Dose reduction or increased dosing interval is necessary based on creatinine clearance.
How to Take
Take orally with food or milk and a full glass of water. Complete the full course of medication as prescribed.
Mechanism of Action
This medicine works by inhibiting two consecutive steps in the bacterial folic acid synthesis pathway. Sulfamethoxazole inhibits dihydropteroate synthetase, and Trimethoprim inhibits dihydrofolate reductase. This synergistic blockade prevents bacterial DNA and RNA synthesis, leading to bacterial death.
Pharmacokinetics
Onset
Therapeutic effects usually begin within 1-4 hours.
Excretion
Primarily excreted via urine.
Half life
Sulfamethoxazole: approximately 9-11 hours; Trimethoprim: approximately 8-10 hours.
Absorption
Both components are well absorbed orally, approximately 90-100%.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to any component of the drug
- Severe renal or hepatic impairment
- Megaloblastic anemia due to folate deficiency
- Infants less than 2 months of age
- Late pregnancy
Drug Interactions
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Phenytoin
May increase phenytoin plasma concentrations.
Methotrexate
May increase methotrexate toxicity.
Diuretics (Thiazides, Furosemide)
May increase serum potassium levels, especially in elderly patients.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, diarrhea, headache, dizziness, and confusion. Management involves gastric lavage, emesis, and supportive care to maintain fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category C/D. Generally avoided in the first trimester and contraindicated in late pregnancy due to potential for kernicterus in neonates. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to any component of the drug
- Severe renal or hepatic impairment
- Megaloblastic anemia due to folate deficiency
- Infants less than 2 months of age
- Late pregnancy
Drug Interactions
Warfarin
May enhance anticoagulant effect, increasing bleeding risk.
Phenytoin
May increase phenytoin plasma concentrations.
Methotrexate
May increase methotrexate toxicity.
Diuretics (Thiazides, Furosemide)
May increase serum potassium levels, especially in elderly patients.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, diarrhea, headache, dizziness, and confusion. Management involves gastric lavage, emesis, and supportive care to maintain fluid and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category C/D. Generally avoided in the first trimester and contraindicated in late pregnancy due to potential for kernicterus in neonates. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Co-trimoxazole has undergone extensive clinical trials demonstrating its efficacy and safety profile for various bacterial infections since its introduction.
Lab Monitoring
- Complete Blood Count (CBC) with differential
- Renal function tests (e.g., serum creatinine)
- Liver function tests
Doctor Notes
- Consider patient's folate status before prescribing.
- Monitor for adverse effects, especially dermatologic reactions and hematological abnormalities.
- Adjust dose in renal impairment.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Drink plenty of fluids while taking this medicine.
- Report any severe rash or unusual bruising/bleeding to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or blurred vision in some individuals. Exercise caution when driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid prolonged exposure to direct sunlight and use sunscreen, as this medication can increase skin sensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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