Deplex
Generic Name
Cyproheptadine Hydrochloride
Manufacturer
Mediplex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deplex 5 mg syrup | ৳ 26.50 | N/A |
Description
Overview of the medicine
Deplex 5 mg Syrup is an antihistamine used to relieve allergy symptoms like runny nose, sneezing, and watery eyes. It also acts as an appetite stimulant, commonly prescribed for weight gain in children and adults who have poor eating habits.
Uses & Indications
Dosage
Adults
Adults: 2 mg (2 ml) to 4 mg (4 ml) three to four times a day. Maximum daily dose should not exceed 0.5 mg/kg.
Elderly
Elderly: Start with a lower dose (e.g., 2 mg twice daily) and adjust according to response and tolerability.
Renal_impairment
Renal impairment: Use with caution, reduced dosage may be necessary.
How to Take
Oral administration. Administer with food or milk to minimize gastric upset. Use a calibrated measuring spoon or cup provided with the syrup for accurate dosing.
Mechanism of Action
Cyproheptadine is a serotonin and H1-histamine antagonist. It competes with histamine for H1-receptor sites on effector cells, thereby preventing histamine-mediated allergic reactions. Its appetite stimulant effect is thought to be related to its serotonin antagonistic properties in the hypothalamus.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted in the urine (around 2-20% as unchanged drug, remainder as metabolites) and feces.
Half life
Approximately 8 hours
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Cyproheptadine or any component of the formulation
- Newborns or premature infants
- Breastfeeding mothers
- Elderly or debilitated patients with glaucoma, prostatic hypertrophy, or stenosing peptic ulcer
- Patients taking MAO inhibitors
- Angle-closure glaucoma
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of Cyproheptadine.
Anticholinergics
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, urinary retention).
CNS Depressants (e.g., alcohol, hypnotics, sedatives, tranquilizers)
Additive CNS depressant effects may occur.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Do not freeze.
Overdose
Symptoms include somnolence, dizziness, ataxia, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in children, excitement, hallucinations, tremors, and convulsions. Management involves symptomatic and supportive measures. Gastric lavage or activated charcoal may be considered. Do not induce vomiting.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Contraindicated in breastfeeding mothers as it may be excreted in breast milk and may cause adverse effects in infants.
Side Effects
Contraindications
- Hypersensitivity to Cyproheptadine or any component of the formulation
- Newborns or premature infants
- Breastfeeding mothers
- Elderly or debilitated patients with glaucoma, prostatic hypertrophy, or stenosing peptic ulcer
- Patients taking MAO inhibitors
- Angle-closure glaucoma
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of Cyproheptadine.
Anticholinergics
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, urinary retention).
CNS Depressants (e.g., alcohol, hypnotics, sedatives, tranquilizers)
Additive CNS depressant effects may occur.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Do not freeze.
Overdose
Symptoms include somnolence, dizziness, ataxia, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in children, excitement, hallucinations, tremors, and convulsions. Management involves symptomatic and supportive measures. Gastric lavage or activated charcoal may be considered. Do not induce vomiting.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Contraindicated in breastfeeding mothers as it may be excreted in breast milk and may cause adverse effects in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Clinical studies have shown Cyproheptadine to be effective in managing allergic symptoms and stimulating appetite.
Lab Monitoring
- None routinely required. Monitor complete blood count and liver function tests in long-term therapy or if symptoms warrant.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness.
- Counsel parents on proper dosing for children and to report any paradoxical excitement.
- Monitor for anticholinergic side effects, especially in elderly patients.
Patient Guidelines
- Do not drive or operate heavy machinery until you know how this medicine affects you.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
- Do not stop taking the medicine abruptly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine can cause drowsiness and dizziness. Avoid driving or operating machinery until you are certain of its effects.
Lifestyle Advice
- Maintain a balanced diet to support healthy weight gain (if used for appetite stimulation).
- Ensure adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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