Derbicil
Generic Name
Betamethasone Valerate 0.1% Cream
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| derbicil 1 cream | ৳ 50.00 | N/A |
Description
Overview of the medicine
Derbicil-1-cream contains Betamethasone Valerate 0.1%, a potent corticosteroid used for various inflammatory and pruritic skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area once or twice daily.
Elderly
Same as adults, but caution advised due to potential for skin thinning and increased systemic absorption.
Renal_impairment
No specific dose adjustment required for topical use, as systemic absorption is minimal.
How to Take
For external use only. Apply a thin film to the affected skin area and rub in gently. Do not apply to open wounds or mucous membranes. Wash hands thoroughly after application.
Mechanism of Action
Betamethasone Valerate is a potent corticosteroid that works by inhibiting the release of chemicals that cause inflammation, such as prostaglandins and leukotrienes. It also constricts blood vessels and reduces cell proliferation, thereby decreasing swelling, redness, and itching.
Pharmacokinetics
Onset
Relief of symptoms typically within a few days of application.
Excretion
Excreted mainly via the kidneys, with some biliary excretion.
Half life
Not well-defined for topical application due to minimal systemic absorption.
Absorption
Systemic absorption is minimal through intact skin, but increases with skin damage, occlusion, or application to large surface areas.
Metabolism
Metabolized primarily in the liver, even if absorbed systemically.
Side Effects
Contraindications
- Hypersensitivity to betamethasone or any component of the cream
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Fungal, viral, or bacterial skin infections (untreated)
- Pruritus without inflammation
Drug Interactions
Systemic Corticosteroids
Increased risk of systemic effects if significant absorption occurs, especially with prolonged or extensive use.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical corticosteroids is unlikely. Chronic overdose or misuse may lead to hypercortisolism (Cushing's syndrome symptoms). Management is symptomatic.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant, and under medical supervision. Avoid prolonged or extensive use.
Side Effects
Contraindications
- Hypersensitivity to betamethasone or any component of the cream
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Fungal, viral, or bacterial skin infections (untreated)
- Pruritus without inflammation
Drug Interactions
Systemic Corticosteroids
Increased risk of systemic effects if significant absorption occurs, especially with prolonged or extensive use.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical corticosteroids is unlikely. Chronic overdose or misuse may lead to hypercortisolism (Cushing's syndrome symptoms). Management is symptomatic.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant, and under medical supervision. Avoid prolonged or extensive use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Betamethasone valerate has been extensively studied for efficacy and safety in various dermatological conditions in numerous clinical trials. Data consistently supports its use as a potent topical corticosteroid.
Lab Monitoring
- Adrenal function tests (if extensive or prolonged use is suspected to cause systemic absorption).
Doctor Notes
- Advise patients on appropriate application technique and duration to minimize systemic absorption and local side effects.
- Monitor for signs of local skin reactions (e.g., atrophy, telangiectasia) and systemic absorption (e.g., adrenal suppression), especially in pediatric patients, elderly, or with extensive use on large body surface areas or under occlusion.
- Educate patients on avoiding use on eyes, face, and genital areas unless specifically directed and for short periods.
- Consider step-down therapy or less potent steroids for maintenance if long-term treatment is required.
Patient Guidelines
- Use only as directed by your doctor.
- Do not use for longer than prescribed.
- Avoid contact with eyes, nose, mouth, or other mucous membranes.
- Do not cover the treated area with occlusive dressings unless advised by a doctor.
- Wash hands thoroughly after application.
Missed Dose Advice
Apply the missed dose as soon as you remember, then continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Derbicil-1-cream is not expected to affect the ability to drive or operate machinery, as it is a topical preparation.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants or allergens that trigger your skin condition.
- Moisturize skin regularly as advised by your doctor.
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