Dermaskin
Generic Name
Betamethasone Valerate + Gentamicin Sulfate + Miconazole Nitrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dermaskin 2 w ointment | ৳ 140.00 | N/A |
Description
Overview of the medicine
Dermaskin cream is a topical medication combining a potent corticosteroid (Betamethasone), an aminoglycoside antibiotic (Gentamicin), and an antifungal agent (Miconazole). It is used to treat various inflammatory skin conditions complicated by secondary bacterial and/or fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily. Do not use for more than 7 days without medical review.
Elderly
No specific dosage adjustment needed, use with caution due to thinner skin.
Renal_impairment
Minimal systemic absorption, unlikely to require dosage adjustment.
How to Take
For external use only. Wash hands before and after application. Apply a thin layer to the affected area and gently rub in. Avoid contact with eyes and mucous membranes.
Mechanism of Action
Betamethasone reduces inflammation and itching by inhibiting phospholipase A2. Gentamicin acts as a broad-spectrum antibiotic by inhibiting bacterial protein synthesis. Miconazole inhibits fungal ergosterol synthesis, disrupting fungal cell membrane integrity.
Pharmacokinetics
Onset
Within hours for anti-inflammatory effect.
Excretion
Mainly renal for systemically absorbed components.
Half life
Not well-defined for topical application, systemic half-life of components vary.
Absorption
Minimal systemic absorption, but can be increased with occlusive dressings or on damaged skin.
Metabolism
Primarily hepatic for systemically absorbed components.
Side Effects
Contraindications
- Hypersensitivity to any component
- Viral skin infections (e.g., herpes simplex, varicella)
- Fungal infections (uncomplicated, where corticosteroids are contraindicated)
- Bacterial skin infections (uncomplicated)
- Tuberculosis of the skin
- Acne vulgaris, rosacea
- Perioral dermatitis
- Perianal and genital pruritus
- Children under 2 years of age
Drug Interactions
No significant systemic drug interactions
No significant systemic drug interactions are expected with topical use. However, prolonged use of large quantities may lead to systemic effects of corticosteroids, which could interact with oral anticoagulants, antidiabetics, etc.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is rare. Prolonged or excessive use may lead to local side effects (e.g., skin thinning) or systemic corticosteroid effects (e.g., Cushing's syndrome symptoms). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Avoid prolonged use or application to large areas.
Side Effects
Contraindications
- Hypersensitivity to any component
- Viral skin infections (e.g., herpes simplex, varicella)
- Fungal infections (uncomplicated, where corticosteroids are contraindicated)
- Bacterial skin infections (uncomplicated)
- Tuberculosis of the skin
- Acne vulgaris, rosacea
- Perioral dermatitis
- Perianal and genital pruritus
- Children under 2 years of age
Drug Interactions
No significant systemic drug interactions
No significant systemic drug interactions are expected with topical use. However, prolonged use of large quantities may lead to systemic effects of corticosteroids, which could interact with oral anticoagulants, antidiabetics, etc.
Storage
Store below 25°C. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is rare. Prolonged or excessive use may lead to local side effects (e.g., skin thinning) or systemic corticosteroid effects (e.g., Cushing's syndrome symptoms). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Avoid prolonged use or application to large areas.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and drugstores nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available, likely off-patent
Clinical Trials
Specific clinical trial data for this exact combination under the brand 'Dermaskin' may not be publicly available. Efficacy and safety are established through studies on individual components and similar combinations.
Lab Monitoring
- Not generally required for short-term topical use. For prolonged or extensive use, consider monitoring for systemic corticosteroid effects (e.g., plasma cortisol levels).
Doctor Notes
- Advise patients on appropriate application technique and duration.
- Caution against unsupervised long-term use, especially on sensitive areas or in children.
- Educate on signs of worsening infection or steroid side effects.
Patient Guidelines
- Use exactly as directed by your doctor.
- Do not cover the treated area with bandages or other dressings unless advised by your doctor.
- Avoid using on the face, groin, or underarms unless specifically directed.
- Do not use for longer than prescribed, especially in children.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra medicine to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants that may worsen your skin condition.
- Wear loose-fitting clothing to prevent irritation of affected areas.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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