Dermatas N
Generic Name
Betamethasone Valerate + Neomycin Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dermatas n 05 mg cream | ৳ 70.00 | N/A |
Description
Overview of the medicine
Dermatas N Cream is a combination topical medication containing Betamethasone Valerate, a potent corticosteroid, and Neomycin Sulfate, a broad-spectrum antibiotic. It is used to treat inflammatory skin conditions such as eczema and psoriasis that are complicated by bacterial infections or are at risk of secondary infection.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area 2-3 times daily. Gently rub in. Treatment should not exceed 7 days without medical review.
Elderly
Same as adults, but caution should be exercised with prolonged use due to increased risk of skin thinning and absorption.
Renal_impairment
No specific dosage adjustment is generally required for topical use due to minimal systemic absorption. However, caution is advised in severe impairment if extensive application occurs.
How to Take
For external use only. Apply a thin layer to the affected skin area. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes. Do not apply to open wounds or broken skin.
Mechanism of Action
Betamethasone, a corticosteroid, acts by inducing phospholipase A2 inhibitory proteins, thereby inhibiting the release of arachidonic acid and subsequently the formation of inflammatory mediators like prostaglandins and leukotrienes. Neomycin, an aminoglycoside antibiotic, binds to the 30S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis and leading to bacterial cell death.
Pharmacokinetics
Onset
Anti-inflammatory effects typically observed within hours to days. Antibacterial effects begin rapidly upon contact.
Excretion
Absorbed Betamethasone metabolites are excreted primarily via the kidneys. Absorbed Neomycin is excreted largely unchanged by the kidneys.
Half life
Not precisely defined for topical application. Systemic Betamethasone has a biological half-life of 3-5 hours. Systemic Neomycin has a serum half-life of 2-3 hours.
Absorption
Limited systemic absorption, especially through intact skin. Absorption may increase with occlusion, inflammation, or large surface areas. Neomycin absorption is minimal.
Metabolism
Betamethasone is primarily metabolized in the liver. Neomycin is not significantly metabolized.
Side Effects
Contraindications
- Hypersensitivity to Betamethasone, Neomycin, or any other aminoglycoside antibiotics or excipients.
- Primary cutaneous viral infections (e.g., Herpes simplex, Varicella).
- Primary fungal or yeast infections of the skin.
- Primary bacterial infections (e.g., impetigo, pyoderma) without concurrent specific antibacterial therapy.
- Acne rosacea, acne vulgaris, perioral dermatitis.
- Pruritus without inflammation.
- Perforated eardrum when applied in or near the ear canal.
- Vaccination reactions.
Drug Interactions
Other topical corticosteroids
Concurrent use of other topical corticosteroids may increase systemic absorption and the risk of adverse effects.
Systemic aminoglycoside antibiotics
Although systemic absorption of topical neomycin is minimal, concurrent use with systemic aminoglycosides could theoretically increase the risk of ototoxicity or nephrotoxicity, especially with extensive application to broken skin.
Storage
Store below 25°C. Protect from light and moisture. Do not freeze. Keep out of reach of children. Do not use after the expiry date.
Overdose
Systemic overdose is unlikely with appropriate topical use. Prolonged and extensive use may lead to systemic corticosteroid effects (e.g., adrenal suppression, Cushing's syndrome) or, rarely, neomycin-related ototoxicity or nephrotoxicity. Treatment is symptomatic and supportive; gradual withdrawal of the corticosteroid is advised if systemic effects occur.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Avoid large areas, prolonged use, or occlusive dressings. Neomycin can cross the placenta. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date, as indicated on the packaging.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
DGDA Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical data and long-standing therapeutic use support the efficacy and safety of topical corticosteroids and neomycin combinations for their indicated uses, with numerous studies demonstrating their effectiveness in managing inflammatory skin conditions complicated by bacterial infections.
Lab Monitoring
- Not routinely required for typical topical use. In cases of extensive or prolonged use, especially in children, monitoring for adrenal axis suppression (e.g., plasma cortisol levels) may be considered.
Doctor Notes
- Re-evaluate diagnosis if there is no improvement within 7 days or if the condition worsens.
- Not indicated for primary fungal or viral infections; ensure proper diagnosis before prescribing.
- Avoid abrupt discontinuation after prolonged use to prevent rebound effects; taper off if necessary.
- Advise patients on appropriate application technique and duration of use to minimize adverse effects.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not use for longer than the recommended period (usually not more than 7 days) without re-evaluation by a doctor.
- Avoid applying to the face, groin, or axillae unless specifically instructed by a doctor.
- Do not cover the treated area with occlusive dressings, bandages, or diapers unless directed by your doctor.
- Inform your doctor if your condition worsens or shows no improvement after 7 days.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Dermatas N Cream is not known to affect the ability to drive or operate machinery, as it is a topical preparation with minimal systemic absorption.
Lifestyle Advice
- Keep the affected skin area clean and dry. Avoid harsh soaps, detergents, or other irritants that might worsen skin conditions.
- Wear loose-fitting clothing over the treated area to prevent irritation.
- Avoid scratching the affected area to prevent further skin damage and infection.
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