Desgud
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desgud 5 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat conditions caused by too much stomach acid, such as gastroesophageal reflux disease (GERD), stomach ulcers, and to help heal a damaged esophagus.
Uses & Indications
Dosage
Adults
For GERD: 20 mg or 40 mg once daily for 4 to 8 weeks. For Erosive Esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. For H. pylori eradication: 40 mg once daily for 10 days in combination with amoxicillin and clarithromycin.
Elderly
No specific dosage adjustment is generally required for elderly patients based on age alone.
Renal_impairment
No dosage adjustment is generally required for patients with renal impairment.
How to Take
Take orally at least one hour before a meal. Swallow the capsule whole with water. Do not chew, crush, or open the capsule.
Mechanism of Action
Esomeprazole selectively inhibits the gastric H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step of acid secretion and reducing gastric acid production.
Pharmacokinetics
Onset
Within 1 hour of administration.
Excretion
Eliminated primarily by the kidneys (approximately 80%) and in feces (approximately 20%).
Half life
Approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose and increases to 89% with repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
May decrease the metabolism of diazepam, increasing its concentration and potentially leading to toxicity.
Warfarin
Monitor INR carefully due to potential for increased bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to its active metabolite. Avoid concomitant use.
Methotrexate
May increase methotrexate levels and prolong its elimination, potentially leading to methotrexate toxicity. Consider temporary discontinuation of esomeprazole.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. No specific antidote is known. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown whether esomeprazole is excreted in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide, Hospitals
Approval Status
Approved by DGDA
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of esomeprazole in the treatment of GERD, erosive esophagitis, H. pylori eradication, and other acid-related conditions.
Lab Monitoring
- No routine laboratory monitoring is typically required. However, long-term use may warrant monitoring for vitamin B12 levels and magnesium levels.
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic effect.
- Advise patients on lifestyle modifications to complement drug therapy.
- Be aware of potential drug interactions, especially with clopidogrel and methotrexate.
- Monitor for signs of C. difficile infection and hypomagnesemia in long-term users.
Patient Guidelines
- Take Desgud exactly as prescribed by your doctor.
- Swallow the capsules whole; do not chew or crush them.
- If you have difficulty swallowing, the capsule can be opened and the contents mixed with a small amount of water or apple juice and taken immediately. Do not store for later use.
- Take the medicine at least one hour before a meal.
- Complete the full course of treatment even if symptoms improve.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Esomeprazole may cause dizziness, blurred vision, or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn (e.g., fatty foods, spicy foods, caffeine, alcohol, acidic juices).
- Eat smaller, more frequent meals instead of large ones.
- Avoid lying down for at least 2-3 hours after eating.
- Elevate the head of your bed if you experience nighttime reflux.
- Maintain a healthy weight.
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Global Brand Names
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