Deslor-Kids
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deslor kids 05 mg pediatric drop | ৳ 25.08 | N/A |
Description
Overview of the medicine
Desloratadine is a non-sedating antihistamine used to relieve symptoms associated with allergic rhinitis (including perennial allergic rhinitis) and chronic idiopathic urticaria in children.
Uses & Indications
Dosage
Adults
For children 6-11 months: 1 mg (2 mL) once daily; 1-5 years: 1.25 mg (2.5 mL) once daily; 6-11 years: 2.5 mg (5 mL) once daily.
Elderly
Not applicable for pediatric drops. Consult physician for adult formulations.
Renal_impairment
For patients with renal impairment, a lower starting dose (e.g., 0.5 mg every other day for children 6-11 months) or less frequent administration may be considered. Consult a physician.
How to Take
For oral administration. Can be taken with or without food. Measure the dose accurately using the provided dropper or measuring spoon.
Mechanism of Action
Desloratadine is a potent, selective, peripheral H1-receptor antagonist. It inhibits histamine release from mast cells and basophils, and also inhibits other allergic inflammatory mediators.
Pharmacokinetics
Onset
Symptomatic relief usually occurs within 30 minutes to 1 hour.
Excretion
Excreted primarily via urine and feces as conjugated metabolites.
Half life
The elimination half-life is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- History of hypersensitivity reactions to antihistamines.
Drug Interactions
Cimetidine
Concomitant administration with cimetidine resulted in increased plasma concentrations of desloratadine.
Fluoxetine
Concomitant administration with fluoxetine resulted in increased plasma concentrations of desloratadine.
Erythromycin
Concomitant administration with erythromycin resulted in increased plasma concentrations of desloratadine.
Ketoconazole
Concomitant administration with ketoconazole resulted in increased plasma concentrations of desloratadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
In the event of an overdose, symptomatic and supportive measures should be initiated immediately. Desloratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Desloratadine is not recommended during pregnancy or lactation unless the potential benefits outweigh the potential risks. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- History of hypersensitivity reactions to antihistamines.
Drug Interactions
Cimetidine
Concomitant administration with cimetidine resulted in increased plasma concentrations of desloratadine.
Fluoxetine
Concomitant administration with fluoxetine resulted in increased plasma concentrations of desloratadine.
Erythromycin
Concomitant administration with erythromycin resulted in increased plasma concentrations of desloratadine.
Ketoconazole
Concomitant administration with ketoconazole resulted in increased plasma concentrations of desloratadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
In the event of an overdose, symptomatic and supportive measures should be initiated immediately. Desloratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Desloratadine is not recommended during pregnancy or lactation unless the potential benefits outweigh the potential risks. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture. Refer to product packaging for specific expiration date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic
Clinical Trials
Desloratadine has been extensively studied in various clinical trials for its efficacy and safety in pediatric populations for the treatment of allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No routine laboratory monitoring is typically required for desloratadine. In rare cases of suspected liver dysfunction, liver function tests may be considered.
Doctor Notes
- Emphasize the importance of accurate dose measurement to parents or caregivers.
- Counsel on potential drug interactions, especially with CYP3A4 and CYP2D6 inhibitors.
- Advise monitoring for any signs of hypersensitivity reactions, especially in young children.
- Reassure parents that desloratadine is generally non-sedating for children.
Patient Guidelines
- Always follow the doctor's prescribed dosage and instructions.
- Measure the dose accurately using the provided measuring device.
- Do not exceed the recommended dose.
- Shake the bottle well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Desloratadine is generally non-sedating. However, individual responses may vary. Caution is advised if performing tasks requiring mental alertness, such as driving or operating machinery, until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger symptoms.
- Maintain a clean environment to reduce exposure to dust mites and pollen.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.