desloratadine
Generic Name
desloratadine-5-mg-tablet
Manufacturer
Various Pharmaceutical Companies
Country
Global, including Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desloratadine 5 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Desloratadine is a non-sedating antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It is an active metabolite of loratadine.
Uses & Indications
Dosage
Adults
5 mg once daily.
Elderly
No specific dosage adjustment is generally required, but caution should be exercised.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Take orally with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine is a long-acting, non-sedating, selective peripheral histamine H1-receptor antagonist. It inhibits the release of histamine from mast cells and basophils and blocks the H1 receptors, thereby alleviating allergic symptoms.
Pharmacokinetics
Onset
Within 1 to 3 hours.
Excretion
Approximately 87% of the dose is excreted in urine and feces within 10 days.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, followed by glucuronidation. CYP2D6 is involved to a minor extent.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increased plasma concentration of desloratadine.
Fluoxetine
Increased plasma concentration of desloratadine.
Azithromycin
Increased plasma concentration of desloratadine.
Erythromycin
Increased plasma concentration of desloratadine.
Ketoconazole
Increased plasma concentration of desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management should be symptomatic and supportive, including general measures to remove unabsorbed drug and monitor vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as desloratadine is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increased plasma concentration of desloratadine.
Fluoxetine
Increased plasma concentration of desloratadine.
Azithromycin
Increased plasma concentration of desloratadine.
Erythromycin
Increased plasma concentration of desloratadine.
Ketoconazole
Increased plasma concentration of desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management should be symptomatic and supportive, including general measures to remove unabsorbed drug and monitor vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as desloratadine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, specific to manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated desloratadine's efficacy and safety in treating symptoms of allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific laboratory monitoring is routinely required.
Doctor Notes
- Consider dose adjustment in patients with severe renal or hepatic impairment.
- Advise patients that while generally non-sedating, individual responses to antihistamines can vary.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Avoid alcohol if it causes drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Although desloratadine is generally non-sedating, individual responses can vary. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good hydration.
- Avoid smoking and exposure to smoke.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.