Desolet
Generic Name
Desogestrel + Ethinylestradiol
Manufacturer
Sample Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desolet 5 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Desolet is a combined oral contraceptive pill containing desogestrel (a progestogen) and ethinylestradiol (an estrogen), used to prevent pregnancy.
Uses & Indications
Dosage
Adults
One tablet daily at the same time for 21 consecutive days, followed by a 7-day pill-free interval. Start new pack after 7 days.
Elderly
Not indicated for post-menopausal women.
Renal_impairment
No specific dose adjustment needed, but caution advised.
How to Take
Take orally with water, at the same time each day, with or without food.
Mechanism of Action
Suppresses ovulation, thickens cervical mucus to prevent sperm penetration, and alters the endometrium to inhibit implantation.
Pharmacokinetics
Onset
Contraceptive effect usually starts after 7 consecutive days of active pills, provided initiated correctly.
Excretion
Mainly through urine and feces as metabolites.
Half life
Desogestrel: 30-38 hours; Ethinylestradiol: 18-24 hours.
Absorption
Rapidly absorbed after oral administration.
Metabolism
Extensively metabolized in the liver to active (e.g., etonogestrel from desogestrel) and inactive metabolites.
Side Effects
Contraindications
- Current or history of thrombosis (venous or arterial)
- Severe liver disease
- Known or suspected breast cancer or other hormone-sensitive cancers
- Undiagnosed vaginal bleeding
- Pregnancy
Drug Interactions
Grapefruit juice
Can increase plasma levels of ethinylestradiol.
Enzyme-inducing drugs (e.g., rifampicin, phenytoin, carbamazepine, St. John's Wort)
May reduce contraceptive efficacy.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, and vaginal bleeding in females. Treatment is symptomatic.
Pregnancy & Lactation
Contraindicated in pregnancy. Not recommended during breastfeeding as hormones may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety as a contraceptive.
Lab Monitoring
- Blood pressure monitoring
- Lipid profile (periodically)
- Liver function tests (if symptoms arise)
- Glucose levels (for diabetic patients)
Doctor Notes
- Counsel patients on potential risks, especially VTE and arterial events.
- Emphasize consistent daily intake for maximal efficacy.
- Consider patient's medical history for contraindications.
Patient Guidelines
- Take the pill at the same time every day.
- Do not stop taking the pill without consulting a doctor.
- Use backup contraception if pills are missed or during the first 7 days of starting a new pack.
- Be aware of signs of serious side effects (e.g., DVT, stroke).
Missed Dose Advice
If one pill is missed and less than 12 hours late, take it immediately. If more than 12 hours late or multiple pills missed, follow specific instructions in patient leaflet and use backup contraception.
Driving Precautions
No known effect on ability to drive or operate machinery.
Lifestyle Advice
- Quit smoking to reduce cardiovascular risks.
- Maintain a healthy diet and regular exercise.
- Inform doctor about all medications and medical conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.