Desta
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| desta 25 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Desta syrup, containing Desloratadine, is a non-sedating antihistamine used to relieve symptoms of allergic rhinitis (e.g., sneezing, runny nose, itching, watery eyes) and urticaria (hives). While the product name 'desta-25-mg-syrup' is provided, the typical concentration for Desloratadine syrup is 2.5 mg per 5 mL, which this product usually adheres to. '25 mg' in the name may refer to a specific variant, total content, or a brand identifier, not a per-dose strength.
Uses & Indications
Dosage
Adults
5 mg (10 mL of 2.5 mg/5 mL syrup) once daily.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with renal or hepatic impairment.
Renal_impairment
Patients with severe renal impairment (CrCl < 30 mL/min) should initiate treatment at 5 mg (10 mL of 2.5 mg/5 mL syrup) every other day.
How to Take
Administer orally, with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It inhibits histamine release from mast cells and basophils, and also inhibits a cascade of reactions in allergic inflammation.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted primarily via urine and feces as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, via hydroxylation. Metabolized by CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation
Drug Interactions
Fluoxetine
Increases plasma concentration of desloratadine.
Erythromycin
Increases plasma concentration of desloratadine.
Ketoconazole
Increases plasma concentration of desloratadine.
Storage
Store at controlled room temperature (20-25°C), away from direct light and moisture. Do not freeze.
Overdose
Symptoms may include somnolence, increased heart rate, and headache. In case of overdose, symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; advise caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation
Drug Interactions
Fluoxetine
Increases plasma concentration of desloratadine.
Erythromycin
Increases plasma concentration of desloratadine.
Ketoconazole
Increases plasma concentration of desloratadine.
Storage
Store at controlled room temperature (20-25°C), away from direct light and moisture. Do not freeze.
Overdose
Symptoms may include somnolence, increased heart rate, and headache. In case of overdose, symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; advise caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Desloratadine has been extensively studied in various clinical trials demonstrating efficacy and safety for allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Renal function tests (in patients with renal impairment)
Doctor Notes
- Advise patients to take consistently once daily.
- Counsel on the non-sedating nature, but warn about potential mild drowsiness in sensitive individuals.
- Ensure patients understand proper measuring techniques for syrup doses, especially for pediatric use.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all medications you are taking.
- Avoid alcohol while taking this medicine, as it may increase drowsiness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered non-sedating, but individual responses vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid allergens that trigger your symptoms.
- Maintain good hygiene to reduce exposure to dust mites and pollen.
- Stay hydrated and get adequate rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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