Destacin
Generic Name
Desloratadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| destacin 5 mg tablet | ৳ 2.51 | ৳ 25.10 |
Description
Overview of the medicine
Destacin 5 mg Tablet contains Desloratadine, a non-drowsy antihistamine that provides relief from allergy symptoms like sneezing, runny nose, itchy eyes, and hives without causing significant drowsiness. It is used for seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
5 mg once daily.
Elderly
No dosage adjustment generally needed for elderly patients with normal renal and hepatic function. Caution is advised for patients with renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Take orally, with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It prevents histamine from binding to its H1 receptors, thereby inhibiting the effects of histamine release and reducing allergic symptoms.
Pharmacokinetics
Onset
Within 30 minutes.
Excretion
Primarily excreted in urine (40%) and feces (40%).
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, which is an active metabolite, then further conjugated and excreted.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal impairment may require dose adjustment.
Drug Interactions
Alcohol
Although desloratadine does not potentiate the effects of alcohol, concomitant use should be approached with caution as individual responses may vary.
Ketoconazole, Erythromycin, Cimetidine, Fluoxetine
No clinically significant interactions have been observed. Co-administration of desloratadine with these drugs may slightly increase desloratadine plasma concentrations but without clinical relevance.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment should be initiated immediately. Hemodialysis is not effective in removing desloratadine.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal impairment may require dose adjustment.
Drug Interactions
Alcohol
Although desloratadine does not potentiate the effects of alcohol, concomitant use should be approached with caution as individual responses may vary.
Ketoconazole, Erythromycin, Cimetidine, Fluoxetine
No clinically significant interactions have been observed. Co-administration of desloratadine with these drugs may slightly increase desloratadine plasma concentrations but without clinical relevance.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment should be initiated immediately. Hemodialysis is not effective in removing desloratadine.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies globally (e.g., FDA, DGDA)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated Desloratadine's efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No routine lab monitoring is generally required. Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients that while desloratadine is generally non-sedating, individual responses to antihistamines can vary.
- Emphasize the importance of adherence to the prescribed dosage, especially in patients with renal impairment.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- If you experience any unusual side effects, consult your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Driving Precautions
Although Desloratadine is a non-drowsy antihistamine, it may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid known allergens to reduce the frequency and severity of allergic reactions.
- Maintain good hydration.
- Consider using saline nasal sprays for congestion.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.