Detonix
Generic Name
Thiocolchicoside
Manufacturer
Apex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| detonix 20 mg tablet | ৳ 4.00 | ৳ 60.00 |
Description
Overview of the medicine
Detonix (Thiocolchicoside) is a muscle relaxant used to alleviate painful muscle spasms and conditions like torticollis, lumbago, and other musculoskeletal disorders.
Uses & Indications
Dosage
Adults
4-8 mg twice daily.
Elderly
Lower doses recommended, consult physician.
Renal_impairment
Dose adjustment required, consult physician.
How to Take
Oral, with or without food.
Mechanism of Action
Thiocolchicoside is a semi-synthetic colchicoside derivative with muscle relaxant and analgesic properties. It acts as a GABA-A receptor antagonist and a glycine receptor antagonist, primarily at the spinal cord level, exerting its muscle relaxant effects.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly via urine and feces.
Half life
Approximately 3-4 hours.
Absorption
Rapidly absorbed after oral administration.
Metabolism
Extensively metabolized in the liver to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Thiocolchicoside
- Flaccid paralysis
- Muscle hypotonia
Drug Interactions
Anticoagulants
Monitor for increased bleeding risk.
CNS Depressants
Increased sedation.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to lack of sufficient safety data.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have established its efficacy and safety for muscle spasms. Ongoing studies are exploring its potential in other musculoskeletal conditions.
Lab Monitoring
- No specific routine lab monitoring required. Monitor liver function in prolonged use.
Doctor Notes
- Caution in patients with known history of seizures or epilepsy.
- Advise patients on potential for drowsiness and avoidance of driving.
Patient Guidelines
- Do not exceed the prescribed dose.
- Consult your doctor if symptoms persist.
- Report any unusual side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating machinery, until you know how the medicine affects you.
- Ensure adequate rest to aid recovery.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.