Dexacare
Generic Name
Dexamethasone 0.5 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexacare 05 mg tablet | ৳ 1.00 | ৳ 20.00 |
Description
Overview of the medicine
Dexacare 0.5 mg Tablet contains Dexamethasone, a potent synthetic corticosteroid. It is used for its anti-inflammatory and immunosuppressive effects in various conditions.
Uses & Indications
Dosage
Adults
The dosage of Dexamethasone varies widely depending on the condition being treated and the patient's response. Typical starting doses for inflammatory conditions may range from 0.5 mg to 9 mg daily, usually given in divided doses. Acute severe conditions may require higher initial doses.
Elderly
No specific dose adjustment is generally required, but caution is advised due to increased susceptibility to adverse effects. Start with the lowest effective dose.
Renal_impairment
No specific dose adjustment is usually necessary in patients with renal impairment, but careful monitoring is advised.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
Mechanism of Action
Dexamethasone acts by binding to intracellular glucocorticoid receptors, which then translocate to the nucleus to regulate gene expression, leading to anti-inflammatory and immunosuppressive effects. It inhibits the release of various inflammatory mediators and suppresses the immune response.
Pharmacokinetics
Onset
Anti-inflammatory effects usually begin within 1 hour after oral administration.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 3-4 hours, but its biological half-life (duration of action) is much longer, 18-36 hours due to tissue binding.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes.
Side Effects
Contraindications
- Systemic fungal infections (unless used as an adjunct to antifungal therapy)
- Hypersensitivity to Dexamethasone or any component of the formulation
- Live virus vaccines in patients receiving immunosuppressive doses
Drug Interactions
NSAIDs
Concurrent use increases the risk of gastrointestinal ulceration and bleeding.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; careful monitoring of INR is required.
Diuretics (e.g., Furosemide, Thiazides)
May enhance potassium depletion.
Antidiabetics (e.g., Insulin, Metformin)
Dexamethasone can increase blood glucose levels, requiring adjustment of antidiabetic medication.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Dexamethasone levels, enhancing its effects and side effects.
CYP3A4 Inducers (e.g., Phenytoin, Rifampicin, Carbamazepine)
May reduce Dexamethasone levels, decreasing its effectiveness.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of acute overdose are rare but may include hyperglycemia, fluid retention, and psychiatric disturbances. Chronic overdose leads to Cushing's syndrome symptoms. Treatment is supportive and symptomatic; gradually reduce the dose if it's a chronic overdose.
Pregnancy & Lactation
Pregnancy Category C/D (depending on duration and dose). Use only if the potential benefit outweighs the potential risk to the fetus. Dexamethasone is excreted in breast milk and may cause adverse effects in a nursing infant. A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in retail pharmacies and hospitals
Approval Status
Approved by DGDA/FDA
Patent Status
Generic available (Off-patent)
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for its various indications, including its role in COVID-19 treatment (RECOVERY trial).
Lab Monitoring
- Blood glucose levels (especially in diabetic or predisposed patients)
- Electrolyte levels (potassium, sodium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmologic examination (for long-term use, to check for cataracts/glaucoma)
Doctor Notes
- Emphasize gradual tapering of dose to prevent adrenal crisis.
- Monitor for signs of infection, hyperglycemia, and fluid retention, especially in high-risk patients.
- Counsel patients on bone health, dietary considerations, and reporting adverse effects.
- Assess risk-benefit carefully in pregnant or lactating women.
Patient Guidelines
- Do not stop taking this medicine suddenly, especially after prolonged use, as it can lead to withdrawal symptoms and adrenal crisis. Gradually reduce the dose under medical supervision.
- Take this medicine with food or milk to reduce stomach upset.
- Report any signs of infection, unusual weight gain, swelling, or mood changes to your doctor immediately.
- Avoid close contact with people who have infections (e.g., chickenpox, measles) if you are taking this medicine, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, blurred vision, or changes in mood/behavior in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D to support bone health, especially during long-term therapy.
- Limit sodium intake to help manage fluid retention and blood pressure.
- Engage in regular, moderate exercise to maintain muscle strength and bone density (if not contraindicated by your condition).
- Avoid alcohol consumption as it may increase the risk of gastrointestinal irritation and osteoporosis.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.