Dexaguard
Generic Name
Dexamethasone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexaguard 01 05 eye drop | ৳ 70.00 | N/A |
Description
Overview of the medicine
Dexaguard is a brand name for Dexamethasone, a potent synthetic corticosteroid used for its anti-inflammatory and immunosuppressive effects. It treats various conditions including allergies, inflammatory disorders, autoimmune diseases, and certain cancers.
Uses & Indications
Dosage
Adults
Initial dosage may vary from 0.5 mg to 9 mg daily, depending on the disease being treated and patient response. Typically given in divided doses.
Elderly
Lower doses may be required due to increased sensitivity and potential for adverse effects. Careful monitoring is advised.
Renal_impairment
No specific dose adjustment is usually necessary, but caution is advised in severe renal impairment.
How to Take
Administer orally, preferably with food or milk to minimize gastrointestinal irritation. For injections, follow medical professional guidance.
Mechanism of Action
Dexamethasone acts by binding to specific intracellular glucocorticoid receptors, forming a complex that translocates into the nucleus and modulates gene expression. This leads to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators, thereby reducing inflammation and suppressing the immune response.
Pharmacokinetics
Onset
Oral: 1-2 hours; IV: Rapid.
Excretion
Excreted mainly in the urine, mostly as inactive metabolites.
Half life
Plasma half-life: 3.5-4.5 hours; Biological half-life: 36-54 hours.
Absorption
Rapidly and almost completely absorbed after oral administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Dexamethasone or any component of the formulation
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics
Increased risk of hypokalemia.
Antidiabetics
May reduce the effect of antidiabetic agents, requiring dose adjustment.
Anticoagulants
Altered anticoagulant effects (monitor INR).
Phenytoin, Rifampicin, Barbiturates
May increase the metabolic clearance of corticosteroids, reducing their effectiveness.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely to cause life-threatening effects. Chronic overdose can lead to signs of Cushing's syndrome. Treatment is symptomatic and supportive; gradual withdrawal if chronic overdose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Small amounts pass into breast milk; caution advised during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in all pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials for a wide range of indications, demonstrating its efficacy in anti-inflammatory and immunosuppressive therapy, as well as in specific conditions like COVID-19.
Lab Monitoring
- Blood glucose levels
- Electrolyte balance (especially potassium)
- Blood pressure monitoring
- Bone mineral density (for long-term use)
- Ophthalmologic examination (for long-term use)
Doctor Notes
- Emphasize gradual tapering of dose to prevent adrenal crisis.
- Monitor patients for signs of infection, as corticosteroids can mask symptoms.
- Be aware of potential drug interactions, especially with NSAIDs and antidiabetics.
- Educate patients on potential side effects and the importance of adherence.
Patient Guidelines
- Do not stop taking this medicine abruptly; doses should be tapered gradually under medical supervision.
- Take with food or milk to reduce stomach upset.
- Report any unusual side effects or worsening of condition to your doctor.
- Avoid close contact with people who have infections (e.g., chickenpox, measles) while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double doses.
Driving Precautions
Dexaguard may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a low-sodium diet to minimize fluid retention.
- Ensure adequate calcium and Vitamin D intake for bone health, especially with long-term use.
- Engage in regular, moderate exercise if appropriate, to maintain muscle strength and bone density.
- Avoid alcohol, which can exacerbate stomach irritation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.