Dexigent
Generic Name
Dexlansoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexigent 30 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Dexigent 30 mg Capsule contains dexlansoprazole, a proton pump inhibitor used to reduce stomach acid and treat conditions like GERD (Gastroesophageal Reflux Disease) and erosive esophagitis.
Uses & Indications
Dosage
Adults
For healing EE: 60 mg once daily for up to 8 weeks. For maintenance of EE: 30 mg once daily. For symptomatic non-erosive GERD: 30 mg once daily for 4 weeks.
Elderly
No dosage adjustment is typically necessary for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take orally, with or without food. The capsule should be swallowed whole. For patients who have difficulty swallowing, the capsule may be opened and sprinkled on a tablespoon of applesauce and swallowed immediately.
Mechanism of Action
Dexlansoprazole selectively inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell, blocking the final step of acid production. This leads to a reduction in gastric acid secretion.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily excreted in urine (approx. 60%) and feces (approx. 23%) as metabolites.
Half life
1-2 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 42-47%.
Metabolism
Extensively metabolized in the liver by cytochrome P450 (CYP) enzymes, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Potential for decreased antiplatelet effect.
Atazanavir/Nelfinavir
Decreased plasma concentrations of these antiretrovirals due to increased gastric pH.
Iron Salts, Ketoconazole, Digoxin
Absorption may be altered due to changes in gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation; it is unknown if dexlansoprazole is excreted in human milk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to dexlansoprazole or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Potential for decreased antiplatelet effect.
Atazanavir/Nelfinavir
Decreased plasma concentrations of these antiretrovirals due to increased gastric pH.
Iron Salts, Ketoconazole, Digoxin
Absorption may be altered due to changes in gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
No specific antidote. In case of overdose, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during lactation; it is unknown if dexlansoprazole is excreted in human milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available in many regions
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of dexlansoprazole in the treatment of GERD and erosive esophagitis across various patient populations.
Lab Monitoring
- Monitor magnesium levels in patients expected to be on long-term treatment or who take dexlansoprazole with other drugs like diuretics.
- Consider Vitamin B12 levels in patients on prolonged therapy.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to achieve therapeutic goals.
- Counsel patients on potential long-term risks with PPIs and monitor for adverse effects.
- Be aware of potential drug interactions, especially with narrow therapeutic index medications.
Patient Guidelines
- Take Dexigent exactly as prescribed by your doctor.
- Do not crush, chew, or break the capsule.
- If you experience severe or persistent side effects, contact your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or visual disturbances. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid trigger foods and drinks that worsen GERD symptoms (e.g., spicy, fatty foods, caffeine, alcohol, citrus).
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.