Dexison
Generic Name
Dexamethasone
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
dexison 05 mg tablet | ৳ 0.90 | N/A |
Description
Overview of the medicine
Dexamethasone is a potent synthetic corticosteroid with anti-inflammatory and immunosuppressant properties, used to treat a wide range of conditions.
Uses & Indications
Dosage
Adults
Dosage varies widely depending on the condition being treated. Typical initial adult dosage ranges from 0.5 mg to 9 mg daily, given in divided doses. It should be individualized based on patient response and tolerance.
Elderly
Similar to adult dosage, but caution should be exercised due to increased susceptibility to adverse effects and comorbidities. Start with lower doses.
Renal_impairment
No specific dosage adjustment is usually required for renal impairment, but careful monitoring is advised.
How to Take
Dexison 0.5 mg tablet should be taken orally, with or without food. Taking it with food or milk may help minimize gastrointestinal upset. It is usually taken once daily or in divided doses.
Mechanism of Action
It acts by binding to glucocorticoid receptors, modifying gene expression to reduce inflammation, suppress immune response, and modulate various metabolic processes.
Pharmacokinetics
Onset
Oral: 1-2 hours for anti-inflammatory effects.
Excretion
Mainly excreted in the urine as inactive metabolites.
Half life
Plasma half-life: 3-4.5 hours; Biological half-life: 36-54 hours.
Absorption
Rapid and complete oral absorption.
Metabolism
Primarily hepatic metabolism, mainly by CYP3A4.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to Dexamethasone or any component of the formulation
- Live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding and ulceration.
Antidiabetics (e.g., Insulin)
May increase blood glucose levels, requiring dose adjustment of antidiabetics.
Anticoagulants (e.g., Warfarin)
May alter anticoagulant effects; monitor INR.
Phenytoin, Barbiturates, Rifampicin
May decrease Dexamethasone's effectiveness due to increased metabolism.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium loss.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are typically extensions of the known side effects, such as increased fluid retention, hypertension, hyperglycemia, and adrenal suppression. Management is primarily supportive, focusing on symptom control and gradual withdrawal.
Pregnancy & Lactation
Pregnancy Category C. Dexamethasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk and may cause adverse effects in infants; therefore, caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Dexamethasone has been extensively studied in numerous clinical trials across its wide range of indications, confirming its efficacy and safety profile.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte balance (e.g., potassium)
- Blood pressure monitoring
- Bone mineral density scans (for long-term therapy)
- Ophthalmic examinations (for long-term therapy)
Doctor Notes
- Always emphasize the importance of gradual dose reduction (tapering) to prevent adrenal crisis.
- Monitor patients for signs of infection, hyperglycemia, and hypertension.
- Consider calcium and vitamin D supplementation for patients on long-term therapy to mitigate osteoporosis risk.
- Advise patients to carry identification indicating corticosteroid use.
Patient Guidelines
- Do not stop taking Dexison abruptly; it must be tapered off gradually under medical supervision.
- Take the medication as prescribed, preferably with food to reduce stomach irritation.
- Report any unusual side effects or signs of infection to your doctor promptly.
- Carry a steroid warning card if on long-term therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Dexamethasone may cause dizziness, blurred vision, or muscle weakness in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially during long-term use.
- Engage in regular, moderate exercise to help maintain muscle strength and bone density.
- Avoid close contact with people who are sick, as corticosteroids can suppress the immune system.
- Limit sodium intake to help manage fluid retention and blood pressure.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.