Dexit
Generic Name
Desloratadine 5 mg
Manufacturer
Multiple manufacturers (e.g., Square Pharmaceuticals, Beximco Pharma)
Country
Global, often manufactured locally
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexit 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Dexit 5 mg tablet contains desloratadine, a non-drowsy antihistamine. It is used to relieve allergy symptoms such as sneezing, runny nose, itchy watery eyes, and hives (urticaria).
Uses & Indications
Dosage
Adults
One 5 mg tablet once daily.
Elderly
No dosage adjustment generally required, but caution is advised in patients with renal or hepatic impairment.
Renal_impairment
For patients with renal or hepatic impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Take orally, with or without food. Do not chew or crush the tablet, swallow whole. For maximum benefit, take at the same time each day.
Mechanism of Action
Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby alleviating allergy symptoms. It also inhibits the release of histamine from mast cells and blocks various inflammatory mediators.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Excreted in urine and feces as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8.
Side Effects
Contraindications
- Known hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal or hepatic impairment (requires dose adjustment).
Drug Interactions
Cimetidine
Concomitant use may increase desloratadine plasma concentrations.
Fluoxetine
Concomitant use may increase desloratadine plasma concentrations.
Erythromycin
Concomitant use may increase desloratadine plasma concentrations.
Ketoconazole
Concomitant use may increase desloratadine plasma concentrations.
Storage
Store below 30°C (86°F) in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, headache, and palpitations. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; caution should be exercised when administered to nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Patients with severe renal or hepatic impairment (requires dose adjustment).
Drug Interactions
Cimetidine
Concomitant use may increase desloratadine plasma concentrations.
Fluoxetine
Concomitant use may increase desloratadine plasma concentrations.
Erythromycin
Concomitant use may increase desloratadine plasma concentrations.
Ketoconazole
Concomitant use may increase desloratadine plasma concentrations.
Storage
Store below 30°C (86°F) in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, headache, and palpitations. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; caution should be exercised when administered to nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, as indicated on the packaging.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Generic available, patents expired
Clinical Trials
Extensive clinical trials have demonstrated desloratadine's efficacy and safety for treating allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No routine lab monitoring is generally required. Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Reassure patients about the non-sedating profile, but advise caution for initial doses.
- Emphasize consistent daily dosing for optimal allergy control.
- Monitor patients with renal or hepatic impairment for potential dose adjustments.
- Advise against concomitant use of other antihistamines or sedatives without consultation.
Patient Guidelines
- Take one tablet once daily as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist about all other medications, supplements, and herbal products you are taking.
- If symptoms persist or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Desloratadine is generally considered non-sedating, but individual responses vary. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid known allergens as much as possible to reduce the frequency and severity of allergy symptoms.
- Maintain good hydration.
- Get adequate rest to support your immune system.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.