Dextrop
Generic Name
Dextromethorphan Hydrobromide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dextrop 10 mg syrup | ৳ 55.00 | N/A |
Description
Overview of the medicine
Dextrop 10 mg syrup is an antitussive medication containing Dextromethorphan Hydrobromide, used to temporarily relieve coughs caused by minor throat and bronchial irritation, common cold, or flu.
Uses & Indications
Dosage
Adults
10-20 mg (1-2 teaspoons) every 4 hours, or 30 mg (3 teaspoons) every 6-8 hours, not to exceed 120 mg in 24 hours.
Elderly
Same as adult dosage, but caution with other medications.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe impairment.
How to Take
Oral. May be taken with or without food. Use measuring spoon/cup provided for accurate dosing.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla oblongata to suppress the cough reflex. It elevates the threshold for coughing without affecting ciliary activity or mucus expectoration.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Excreted primarily via the kidneys as unchanged drug and metabolites.
Half life
2-4 hours (for extensive metabolizers), up to 15-30 hours (for poor metabolizers).
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver by CYP2D6 to its active metabolite, dextrorphan, and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to dextromethorphan or any component of the formulation.
- Concurrent use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing MAOIs.
- Children under 4 years of age (generally for cough/cold products).
Drug Interactions
Alcohol and other CNS depressants
May increase CNS depression.
MAOIs (Monoamine Oxidase Inhibitors)
Concomitant use can lead to serotonin syndrome, a potentially life-threatening reaction.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 30°C/86°F), away from direct light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, drowsiness, blurred vision, nystagmus, ataxia, respiratory depression, and serotonin syndrome. Treatment is supportive, potentially including activated charcoal, naloxone (for severe cases of respiratory depression), and serotonin antagonists.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may pass into breast milk; use with caution during lactation and consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, refer to product label for specific expiry.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Dextromethorphan has been extensively studied and is widely used for cough suppression; numerous trials support its efficacy and safety at recommended doses. Research also exists on its potential non-antitussive uses.
Lab Monitoring
- No routine lab monitoring required for typical use.
Doctor Notes
- Counsel patients on potential for drowsiness and avoidance of activities requiring mental alertness.
- Remind patients to check other cold medications for dextromethorphan to avoid inadvertent overdose.
- Advise caution in patients with chronic respiratory conditions like asthma or COPD without consulting a physician due to potential for mucus retention.
- Screen for concurrent use of MAOIs, SSRIs, or other serotonergic agents due to serotonin syndrome risk.
Patient Guidelines
- Do not exceed recommended dose.
- Avoid alcohol while taking this medicine.
- Consult a doctor if cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Drink plenty of fluids to help thin mucus.
- Use a humidifier to moisten the air.
- Avoid irritants like smoke and dust.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.