Diacon
Generic Name
Gliclazide 80 mg tablet
Manufacturer
XYZ Pharma
Country
Global, widely manufactured
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diacon 80 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Diacon 80 mg tablet contains Gliclazide, an oral hypoglycaemic agent used to control high blood sugar levels in patients with type 2 diabetes mellitus. It stimulates insulin release from the pancreatic beta cells.
Uses & Indications
Dosage
Adults
Initial dose 40-80 mg daily, increasing gradually to 320 mg daily if needed. Doses >160 mg should be given in two divided doses.
Elderly
Similar to adults, but initial doses should be lower (e.g., 40 mg daily) and titrated carefully due to increased risk of hypoglycemia.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment; consider lower doses and close monitoring.
How to Take
Take orally, preferably with breakfast or the first main meal of the day. Swallow whole with water, do not crush or chew.
Mechanism of Action
Gliclazide primarily acts by stimulating insulin secretion from the pancreatic β-cells. It binds to sulfonylurea receptors on the β-cell membrane, leading to the closure of ATP-sensitive potassium channels, depolarization of the membrane, and influx of calcium ions. This influx triggers the release of insulin.
Pharmacokinetics
Onset
Within 1 hour (hypoglycemic effect)
Excretion
Mainly excreted in the urine (60-70%) as metabolites, and about 10-20% in the faeces.
Half life
Approximately 10-12 hours
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic pre-coma and coma
- Diabetic ketoacidosis
- Severe renal or hepatic insufficiency
- Concomitant treatment with miconazole
Drug Interactions
Miconazole
Potentiates the hypoglycemic effect, leading to severe hypoglycemia. Concomitant use is contraindicated.
Anticoagulants (e.g., Warfarin)
Gliclazide may potentiate the effect of anticoagulants, requiring dose adjustment of the anticoagulant.
Phenylbutazone, Alcohol, Sulfonamides, Fluoroquinolones
May enhance the blood glucose lowering effect, increasing risk of hypoglycemia.
Corticosteroids, Danazol, Chlorpromazine, Beta-2 agonists (oral), Ritodrine, Salbutamol (IV), Terbutaline (IV)
May reduce the hypoglycemic effect, leading to increased blood glucose levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hypoglycemia. Management includes glucose administration (oral for mild, IV dextrose for severe) and close monitoring.
Pregnancy & Lactation
Not recommended during pregnancy and breastfeeding. Insulin is the preferred treatment for diabetes in these conditions.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes mellitus
- Diabetic pre-coma and coma
- Diabetic ketoacidosis
- Severe renal or hepatic insufficiency
- Concomitant treatment with miconazole
Drug Interactions
Miconazole
Potentiates the hypoglycemic effect, leading to severe hypoglycemia. Concomitant use is contraindicated.
Anticoagulants (e.g., Warfarin)
Gliclazide may potentiate the effect of anticoagulants, requiring dose adjustment of the anticoagulant.
Phenylbutazone, Alcohol, Sulfonamides, Fluoroquinolones
May enhance the blood glucose lowering effect, increasing risk of hypoglycemia.
Corticosteroids, Danazol, Chlorpromazine, Beta-2 agonists (oral), Ritodrine, Salbutamol (IV), Terbutaline (IV)
May reduce the hypoglycemic effect, leading to increased blood glucose levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hypoglycemia. Management includes glucose administration (oral for mild, IV dextrose for severe) and close monitoring.
Pregnancy & Lactation
Not recommended during pregnancy and breastfeeding. Insulin is the preferred treatment for diabetes in these conditions.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, or as indicated on the pack.
Availability
Available in pharmacies, hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials demonstrating efficacy and safety in type 2 diabetes management. Ongoing research includes long-term cardiovascular outcomes.
Lab Monitoring
- Regular monitoring of blood glucose levels is essential.
- HbA1c levels should be checked every 3-6 months.
- Liver and renal function tests should be performed periodically.
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Advise lifestyle modifications (diet, exercise) alongside medication for optimal control.
- Regularly assess renal and hepatic function, especially in elderly patients.
Patient Guidelines
- Take medicine exactly as prescribed.
- Do not skip meals and maintain a regular diet.
- Be aware of symptoms of hypoglycemia and how to treat it (e.g., consume sugary drinks/snacks).
- Inform your doctor if you experience unusual side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Patients should be aware of the risk of hypoglycemia, which can impair the ability to drive or operate machinery. If hypoglycemia occurs, avoid driving.
Lifestyle Advice
- Maintain a healthy diet, low in sugar and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Monitor blood glucose regularly at home.
- Avoid smoking and limit alcohol consumption.
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Global Brand Names
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