Diactin
Generic Name
Cyproheptadine Hydrochloride
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diactin 5 mg tablet | ৳ 1.50 | ৳ 15.00 |
Description
Overview of the medicine
Diactin 5 mg tablet contains Cyproheptadine Hydrochloride, an antihistamine with antiserotonergic and anticholinergic properties. It is used to relieve symptoms of various allergic conditions and also as an appetite stimulant.
Uses & Indications
Dosage
Adults
For allergies: Initial 4 mg three times daily (TID), maximum 0.5 mg/kg/day or 32 mg/day, whichever is less. For appetite stimulation: 4 mg three times daily.
Elderly
Start with lower doses (e.g., 4 mg once or twice daily) due to increased sensitivity and potential for adverse effects. Dose adjustment based on renal and hepatic function.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Monitor renal function closely.
How to Take
Diactin 5 mg tablet is for oral administration. It can be taken with or without food. Taking it with food may help reduce gastrointestinal upset.
Mechanism of Action
Cyproheptadine acts as a potent H1-receptor antagonist, blocking the effects of histamine and thus reducing allergic symptoms. It also possesses antiserotonergic activity by blocking 5-HT2 receptors, which is thought to contribute to its appetite-stimulating effects.
Pharmacokinetics
Onset
Antihistamine effects usually begin within 15-30 minutes. Appetite stimulating effects may take longer and vary.
Excretion
Mainly excreted in urine (about 40%) and feces (about 2-20%) as metabolites.
Half life
Approximately 16 hours.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are usually reached within 6-9 hours after administration.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation
- Newborns or premature infants
- Breastfeeding mothers
- Angle-closure glaucoma
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Concomitant use with Monoamine Oxidase (MAO) inhibitors
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of antihistamines (e.g., dry mouth, urinary retention).
CNS Depressants
Additive sedative effects may occur with alcohol, sedatives, hypnotics, anxiolytics, and other CNS depressants.
Anticholinergic drugs
May enhance anticholinergic effects when co-administered with other anticholinergic agents.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, ataxia, blurred vision, dry mouth, urinary retention, dilated pupils, and in severe cases, CNS depression or stimulation, convulsions, respiratory depression, and coma. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B (US FDA). Use only if clearly needed and the potential benefits outweigh the potential risks. Not recommended during breastfeeding as it may cause sedation in infants and potentially decrease milk supply.
Side Effects
Contraindications
- Hypersensitivity to cyproheptadine or any component of the formulation
- Newborns or premature infants
- Breastfeeding mothers
- Angle-closure glaucoma
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Concomitant use with Monoamine Oxidase (MAO) inhibitors
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of antihistamines (e.g., dry mouth, urinary retention).
CNS Depressants
Additive sedative effects may occur with alcohol, sedatives, hypnotics, anxiolytics, and other CNS depressants.
Anticholinergic drugs
May enhance anticholinergic effects when co-administered with other anticholinergic agents.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, ataxia, blurred vision, dry mouth, urinary retention, dilated pupils, and in severe cases, CNS depression or stimulation, convulsions, respiratory depression, and coma. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B (US FDA). Use only if clearly needed and the potential benefits outweigh the potential risks. Not recommended during breastfeeding as it may cause sedation in infants and potentially decrease milk supply.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Cyproheptadine has been subject to numerous clinical trials evaluating its efficacy and safety in allergic conditions and as an appetite stimulant. Many studies support its use for these indications, particularly for improving weight in undernourished individuals.
Lab Monitoring
- For long-term therapy, periodic monitoring of complete blood count (CBC) and liver function tests (LFTs) may be advisable.
Doctor Notes
- Educate patients about the sedative effects and advise against activities requiring mental alertness.
- Monitor weight and nutritional status, especially when prescribing for appetite stimulation.
- Exercise caution in elderly patients and those with conditions exacerbated by anticholinergic effects.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid consuming alcohol while taking this medicine.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Diactin 5 mg may cause drowsiness, dizziness, or blurred vision. Patients should be warned not to drive or operate hazardous machinery until they know how the medication affects them.
Lifestyle Advice
- If used for appetite stimulation, combine with a balanced, nutritious diet and appropriate nutritional counseling.
- Stay hydrated by drinking plenty of fluids.
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