Take Diafre 500 mg Tablet orally, preferably with or after meals to reduce gastrointestinal discomfort. Swallow the tablet whole with a glass of water, do not crush or chew it.

Metformin primarily reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. It also increases insulin sensitivity, enhancing peripheral glucose uptake and utilization in muscle cells. Additionally, it delays intestinal glucose absorption. Unlike sulfonylureas, it does not stimulate insulin secretion and therefore does not cause hypoglycemia in monotherapy.

• •Hypersensitivity to metformin or any excipients.
• •Severe renal impairment (eGFR < 30 mL/min/1.73 m²).
• •Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• •Dehydration, severe infection, shock.
• •Hepatic impairment, acute alcohol intoxication.

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose of metformin can lead to lactic acidosis, especially in patients with predisposing factors such as renal impairment. Symptoms include malaise, myalgia, respiratory distress, somnolence, and abdominal distress. Treatment is primarily supportive; hemodialysis is the most effective method for removing lactate and metformin from the blood.

Use during pregnancy is generally not recommended, insulin is preferred. Consult your doctor. Metformin is excreted into breast milk; however, the amount is usually low and considered compatible with breastfeeding. Discuss with your healthcare provider.