Diaprid
Generic Name
Gliclazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diaprid 80 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Gliclazide is an oral hypoglycemic agent of the sulfonylurea class used in the management of type 2 diabetes mellitus. It helps to lower blood glucose levels by stimulating insulin release from the pancreatic beta cells.
Uses & Indications
Dosage
Adults
Initially 40-80 mg daily, taken with breakfast. Adjusted according to response, usually 80-320 mg daily in divided doses. Doses over 160 mg usually given twice daily.
Elderly
Similar to adult dosage, but caution with initial dose and titration due to increased risk of hypoglycemia.
Renal_impairment
Mild to moderate renal impairment may require lower initial doses and careful monitoring. Not recommended for severe renal impairment.
How to Take
Oral, usually taken with food, preferably breakfast, to reduce the risk of gastrointestinal upset and ensure optimal absorption.
Mechanism of Action
Gliclazide binds to sulfonylurea receptors on pancreatic beta-cells, leading to depolarization, which opens voltage-gated calcium channels. The resulting calcium influx stimulates insulin secretion. It also has hemovascular effects.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily via the kidneys as metabolites, with a small amount excreted in feces.
Half life
Approximately 10-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Bioavailability is about 97%.
Metabolism
Extensively metabolized in the liver by CYP2C9, primarily to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Concomitant miconazole treatment
- Pregnancy and lactation
Drug Interactions
Miconazole
Potentiates the hypoglycemic effect, leading to severe hypoglycemia.
Corticosteroids, Diuretics, Estrogens, Progestogens
Can reduce the hypoglycemic effect.
Beta-blockers, ACE inhibitors, NSAIDs, Salicylates, Sulfonamides
Can enhance the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include severe hypoglycemia, which may be treated with oral glucose if conscious, or intravenous glucose/glucagon if unconscious. Hospitalization and monitoring are required.
Pregnancy & Lactation
Not recommended during pregnancy and lactation. Insulin is generally preferred for diabetes management in pregnant women.
Side Effects
Contraindications
- Hypersensitivity to Gliclazide or other sulfonylureas
- Type 1 diabetes
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Concomitant miconazole treatment
- Pregnancy and lactation
Drug Interactions
Miconazole
Potentiates the hypoglycemic effect, leading to severe hypoglycemia.
Corticosteroids, Diuretics, Estrogens, Progestogens
Can reduce the hypoglycemic effect.
Beta-blockers, ACE inhibitors, NSAIDs, Salicylates, Sulfonamides
Can enhance the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include severe hypoglycemia, which may be treated with oral glucose if conscious, or intravenous glucose/glucagon if unconscious. Hospitalization and monitoring are required.
Pregnancy & Lactation
Not recommended during pregnancy and lactation. Insulin is generally preferred for diabetes management in pregnant women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for type 2 diabetes management, demonstrating efficacy and safety profile.
Lab Monitoring
- Blood glucose levels
- HbA1c
- Renal function tests
- Liver function tests
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Regular renal and hepatic function monitoring is crucial, especially in vulnerable populations.
- Consider dose adjustments for concurrent medications.
Patient Guidelines
- Take medicine as prescribed.
- Do not skip meals.
- Monitor blood glucose regularly.
- Be aware of hypoglycemia symptoms and carry a source of sugar.
Missed Dose Advice
If a dose is missed, take it as soon as you remember unless it's almost time for the next dose. Do not double the dose to catch up.
Driving Precautions
Patients should be aware of the risk of hypoglycemia and its effects on driving ability.
Lifestyle Advice
- Healthy diet
- Regular exercise
- Weight management
- Avoiding excessive alcohol
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.