Diaset
Generic Name
Teneligliptin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diaset 50 mg tablet | ৳ 15.11 | ৳ 151.10 |
Description
Overview of the medicine
Teneligliptin is an oral anti-diabetic drug used for the treatment of type 2 diabetes mellitus. It belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. It helps to lower blood glucose levels by increasing the levels of incretin hormones.
Uses & Indications
Dosage
Adults
50 mg once daily, preferably in the morning, with or without food.
Elderly
No specific dose adjustment required based on age, but caution is advised in elderly patients with impaired renal function.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. For severe renal impairment or end-stage renal disease, monitoring is recommended.
How to Take
Orally, once daily, with or without food.
Mechanism of Action
Teneligliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for inactivating incretin hormones (GLP-1 and GIP). By inhibiting DPP-4, teneligliptin increases the levels of active incretin hormones, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon secretion from alpha cells, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
Within hours of administration, sustained blood glucose lowering effect.
Excretion
Excreted via both renal and hepatic routes, with approximately 50% excreted unchanged in urine and feces.
Half life
Approximately 24 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentration reached in 1-2 hours. Bioavailability is high.
Metabolism
Primarily metabolized by cytochrome P450 enzymes (CYP3A4 and CYP2D6) and non-CYP pathways.
Side Effects
Contraindications
- Hypersensitivity to teneligliptin or any component of the tablet
- Type 1 Diabetes Mellitus
- Diabetic ketoacidosis
Drug Interactions
Digoxin
May slightly increase digoxin levels, monitor digoxin concentration.
CYP3A4/2D6 inhibitors/inducers
Co-administration with strong inhibitors or inducers of CYP3A4 and CYP2D6 may alter teneligliptin exposure, though dose adjustment is generally not required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek medical attention. Symptomatic and supportive treatment should be initiated. Teneligliptin is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known whether teneligliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to teneligliptin or any component of the tablet
- Type 1 Diabetes Mellitus
- Diabetic ketoacidosis
Drug Interactions
Digoxin
May slightly increase digoxin levels, monitor digoxin concentration.
CYP3A4/2D6 inhibitors/inducers
Co-administration with strong inhibitors or inducers of CYP3A4 and CYP2D6 may alter teneligliptin exposure, though dose adjustment is generally not required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek medical attention. Symptomatic and supportive treatment should be initiated. Teneligliptin is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known whether teneligliptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities
Patent Status
Patent expired in some regions, generic versions available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of teneligliptin in patients with type 2 diabetes, both as monotherapy and in combination with other anti-diabetic agents.
Lab Monitoring
- HbA1c levels
- Blood glucose levels (fasting and post-prandial)
- Renal function (creatinine, eGFR)
- Liver function tests (ALT, AST)
Doctor Notes
- Advise patients on lifestyle modifications.
- Monitor renal function periodically, especially in elderly patients.
- Caution when co-prescribing with sulfonylureas or insulin due to increased risk of hypoglycemia.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor.
- Monitor your blood glucose regularly.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, teneligliptin does not impair the ability to drive or operate machinery. However, if used in combination with sulfonylureas or insulin, there is a risk of hypoglycemia which may affect driving ability. Patients should be aware of hypoglycemia symptoms.
Lifestyle Advice
- Maintain a healthy diet.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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