Diastat-L
Generic Name
Loratadine
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diastat l 10 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Diastat-L (Loratadine) is a second-generation antihistamine used to relieve symptoms of allergic conditions such as hay fever and chronic urticaria. It effectively blocks histamine, reducing itching, sneezing, and watery eyes without causing significant drowsiness.
Uses & Indications
Dosage
Adults
10 mg once daily.
Elderly
No dosage adjustment generally required, but caution in severe hepatic or renal impairment.
Renal_impairment
For severe renal impairment (creatinine clearance <30 mL/min), 10 mg every other day.
How to Take
Oral administration. May be taken with or without food.
Mechanism of Action
Loratadine is a selective peripheral H1-receptor antagonist. It blocks the action of histamine, a substance produced by the body during an allergic reaction, thereby relieving allergic symptoms.
Pharmacokinetics
Onset
Within 1-3 hours
Excretion
Approximately 40% in urine and 42% in feces over 10 days, primarily as conjugated metabolites.
Half life
Approximately 8.4 hours (Loratadine); 28 hours (Desloratadine, active metabolite)
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver to an active metabolite, desloratadine, primarily by CYP3A4 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to Loratadine or any component of the formulation.
- Children under 2 years of age (syrup formulation might be used under medical supervision).
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine.
Erythromycin
May increase plasma concentrations of loratadine.
Ketoconazole
May increase plasma concentrations of loratadine.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk, so caution is advised in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Loratadine or any component of the formulation.
- Children under 2 years of age (syrup formulation might be used under medical supervision).
Drug Interactions
Cimetidine
May increase plasma concentrations of loratadine.
Erythromycin
May increase plasma concentrations of loratadine.
Ketoconazole
May increase plasma concentrations of loratadine.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk, so caution is advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, drugstores
Approval Status
FDA Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Loratadine for allergic rhinitis and chronic urticaria. Post-marketing surveillance continues to monitor safety.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Renal function tests (in patients with renal impairment)
Doctor Notes
- Advise patients on proper storage and to keep out of reach of children.
- Counsel patients on avoiding known allergens for best therapeutic outcomes.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor or as directed on the label.
- Do not exceed the recommended dose.
- If symptoms do not improve or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Loratadine is generally non-sedating, but some individuals may experience drowsiness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid known allergens that trigger your symptoms.
- Maintain a clean environment to reduce exposure to dust mites and pet dander.
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