Diatrol MR
Generic Name
Gliclazide Modified Release
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diatrol mr 30 mg tablet | ৳ 8.00 | ৳ 80.00 |
| diatrol mr 60 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Diatrol MR is an oral antidiabetic medicine containing Gliclazide Modified Release. It is used to lower blood glucose levels in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Initial dose: 30 mg once daily, taken with breakfast. May be increased to 60 mg, 90 mg, or 120 mg daily, according to blood glucose response, with increments of at least 1 month interval. Maximum recommended dose is 120 mg daily.
Elderly
Similar to adult dosage, but caution is advised due to increased risk of hypoglycemia. Start with a lower dose.
Renal_impairment
In mild to moderate renal impairment, no dose adjustment is usually required. In severe renal impairment, it is generally not recommended.
How to Take
Take the tablet whole with breakfast, once daily. Do not chew or crush the tablet.
Mechanism of Action
Gliclazide primarily stimulates insulin secretion from pancreatic beta cells. It also enhances peripheral insulin sensitivity and reduces hepatic glucose production.
Pharmacokinetics
Onset
Gradual, due to modified release.
Excretion
Primarily excreted in urine (60-70%) and feces (10-20%) as metabolites.
Half life
Approximately 12-20 hours.
Absorption
Well absorbed after oral administration. Modified release formulation ensures sustained plasma concentrations.
Metabolism
Extensively metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic insufficiency
- Hypersensitivity to gliclazide or other sulfonylureas
- Pregnancy and lactation
- Concomitant treatment with miconazole.
Drug Interactions
Miconazole (oral gel, systemic)
Potentiates hypoglycemic effect, potentially leading to coma.
Corticosteroids, danazol, chlorpromazine, diuretics (thiazides), oral contraceptives
May reduce the hypoglycemic effect (hyperglycemia).
Phenylbutazone, alcohol, other antidiabetics, beta-blockers, fluconazole, H2-antagonists, MAOIs, sulfonamides, NSAIDs
May potentiate the hypoglycemic effect.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypoglycemia, which can be treated by administering glucose (oral or intravenous). In severe cases, hospitalization may be required.
Pregnancy & Lactation
Gliclazide is contraindicated during pregnancy and breastfeeding due to potential fetal harm and excretion into breast milk. Insulin is preferred for glycemic control during pregnancy.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
DGDA approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Gliclazide has been extensively studied in various clinical trials demonstrating its efficacy and safety in type 2 diabetes management, particularly in reducing cardiovascular risk (e.g., ADVANCE study).
Lab Monitoring
- Regular monitoring of blood glucose levels (fasting and postprandial)
- HbA1c levels every 3-6 months
- Renal and hepatic function tests periodically.
Doctor Notes
- Advise patients on lifestyle modifications.
- Educate on hypoglycemia symptoms and management.
- Monitor renal and hepatic function, especially in elderly.
- Consider cardiovascular benefits of gliclazide (ADVANCE trial).
Patient Guidelines
- Adhere strictly to dietary recommendations and regular exercise.
- Be aware of symptoms of hypoglycemia and how to manage them (e.g., consume fast-acting carbohydrates).
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Hypoglycemia may impair the ability to concentrate or react. Patients should be advised to take precautions when driving or operating machinery, especially at the start of treatment or after dose changes.
Lifestyle Advice
- Maintain a balanced diet, limit sugar intake.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Regularly monitor blood glucose levels at home.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.