Diavir
Generic Name
Diavir
Manufacturer
Innovapharm Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diavir 2 mg tablet | ৳ 5.00 | N/A |
Description
Overview of the medicine
Diavir 2 mg tablet is an antiviral medication used to treat certain viral infections by inhibiting viral replication.
Uses & Indications
Dosage
Adults
2 mg orally three times daily for 7-10 days, or as directed by physician.
Elderly
Dosage adjustment may be required based on renal function; consult physician.
Renal_impairment
Reduce dose to 2 mg once daily for severe impairment (CrCl < 30 mL/min).
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Diavir is a nucleoside analogue that is phosphorylated intracellularly to its active triphosphate form. This active metabolite competes with natural nucleoside triphosphates for incorporation into viral DNA/RNA, leading to chain termination and inhibition of viral DNA/RNA polymerase, thus preventing viral replication.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Mainly excreted renally as unchanged drug and metabolites.
Half life
Approximately 3-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with bioavailability of approximately 60-70%.
Metabolism
Primarily metabolized in the liver into its active triphosphate form.
Side Effects
Contraindications
- Hypersensitivity to Diavir or any excipients
- Severe hepatic impairment
Drug Interactions
Probenecid
May increase Diavir plasma concentrations due to competition for renal tubular secretion.
Nephrotoxic drugs
Coadministration with other nephrotoxic agents may increase the risk of renal dysfunction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, headache, and renal dysfunction. Treatment is supportive; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Diavir or any excipients
- Severe hepatic impairment
Drug Interactions
Probenecid
May increase Diavir plasma concentrations due to competition for renal tubular secretion.
Nephrotoxic drugs
Coadministration with other nephrotoxic agents may increase the risk of renal dysfunction.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, headache, and renal dysfunction. Treatment is supportive; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Phase III trials demonstrated significant efficacy in reducing viral load and accelerating lesion healing in HSV and VZV infections. Ongoing post-marketing surveillance.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) during prolonged therapy
- Liver function tests (e.g., ALT, AST) periodically
Doctor Notes
- Advise patients on hydration, especially during high-dose therapy.
- Monitor renal function in elderly patients or those with pre-existing renal conditions.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Stay hydrated by drinking plenty of fluids.
- Report any severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue; avoid driving or operating heavy machinery if affected.
Lifestyle Advice
- Avoid close contact with others if you have a contagious viral infection.
- Maintain good hygiene to prevent spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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