Diclofen-SR
Generic Name
Diclofenac Sodium Sustained Release 100 mg Tablet
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diclofen sr 100 mg tablet | ৳ 3.40 | ৳ 34.00 |
Description
Overview of the medicine
Diclofenac Sodium Sustained Release 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and inflammation associated with various conditions.
Uses & Indications
Dosage
Adults
Usually 100 mg once daily. In some cases, a starting dose of 75 mg once daily may be considered.
Elderly
Use with caution and consider starting at the lower end of the dosing range, especially with impaired renal or hepatic function. Monitor for adverse effects.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with mild to moderate renal impairment. Avoid in severe renal impairment.
How to Take
Oral administration. Swallow whole with liquid, preferably with or after food to minimize gastrointestinal upset. Do not crush, chew, or break the tablet.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. The sustained-release formulation provides prolonged effect.
Pharmacokinetics
Onset
Pain relief within 1-2 hours, full therapeutic effect may take longer due to sustained release.
Excretion
Approximately 60% of the dose is excreted in the urine as metabolites, and about 35% is excreted in the bile.
Half life
Approximately 1.2-2 hours for the parent compound, but metabolites have longer half-lives; effective duration is extended with SR formulation.
Absorption
Well absorbed orally. Sustained-release formulation delays peak plasma concentration, typically reached in 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2C9, to hydroxylated metabolites, which are largely inactive.
Side Effects
Contraindications
- •Active gastrointestinal bleeding or peptic ulcer disease
- •Severe heart failure (NYHA Class III-IV)
- •Severe renal impairment (CrCl <30 mL/min) or hepatic impairment
- •Known hypersensitivity to diclofenac, aspirin, or other NSAIDs
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Third trimester of pregnancy
- •Peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, potentially leading to lithium toxicity.
Methotrexate
Increased methotrexate toxicity by reducing its renal clearance.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding when co-administered.
ACE inhibitors/ARBs
Reduced antihypertensive effect; increased risk of renal impairment, especially in dehydrated or elderly patients.
Warfarin and other anticoagulants
Increased risk of bleeding due to additive antiplatelet effects and potential displacement from plasma protein binding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effect; increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children. Do not use after the expiry date.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Less common effects include hypertension, acute renal failure, respiratory depression, and coma. Management is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered within the first hour of ingestion in large overdoses.
Pregnancy & Lactation
Pregnancy: Contraindicated during the third trimester due to risk of premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit outweighs risk, under strict medical supervision. Lactation: Not recommended during breastfeeding as diclofenac passes into breast milk and may cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific details are mentioned on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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