Diliner-DR
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| diliner dr 20 mg dr capsule | ৳ 8.00 | ৳ 48.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that reduces acid secretion in the stomach. It is used to treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Varies based on indication. For GERD, 20-40 mg once daily for 4-8 weeks. For erosive esophagitis, 20-40 mg once daily for 4-8 weeks. For H. pylori eradication, 20 mg twice daily with antibiotics.
Elderly
No specific dosage adjustment required, but caution is advised.
Renal_impairment
No dosage adjustment needed for patients with mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Take the capsule at least one hour before a meal, swallowed whole with water. Do not chew or crush.
Mechanism of Action
Esomeprazole irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in gastric parietal cells, thereby inhibiting the final step in gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted in urine (80%) as metabolites, and the remainder in feces.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 64% with a single 40 mg dose and increases to 89% with repeated once-daily administration. Food delays and decreases absorption but does not significantly affect efficacy.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, particularly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
Increased methotrexate levels, especially in high doses.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptomatic and supportive treatment. No specific antidote.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Lactation: Excreted in human milk; caution advised.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
Increased methotrexate levels, especially in high doses.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptomatic and supportive treatment. No specific antidote.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Lactation: Excreted in human milk; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various acid-related disorders.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Bone mineral density (with prolonged use)
- Vitamin B12 levels (with prolonged use)
Doctor Notes
- Advise patients about potential rebound acid secretion if stopping abruptly.
- Consider alternative diagnoses if symptoms persist or worsen.
- Review concomitant medications for potential interactions.
Patient Guidelines
- Take as directed by your doctor, usually before a meal.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual side effects.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty, acidic foods).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of the bed.
- Quit smoking and reduce alcohol intake.
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Global Brand Names
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