dilock-tr
Generic Name
Diltiazem Extended-Release
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dilock tr 100 mg capsule | ৳ 3.00 | N/A |
Description
Overview of the medicine
Dilock-TR 100 mg Capsule contains Diltiazem Extended-Release, a calcium channel blocker used to treat high blood pressure, chronic stable angina (chest pain), and certain heart rhythm disorders like atrial fibrillation or flutter.
Uses & Indications
Dosage
Adults
For hypertension or angina, typical starting dose for extended-release diltiazem is 120-240 mg orally once daily. Dosage may be titrated based on patient response and tolerability, up to a maximum of 540 mg/day. (Note: 100 mg might be an initial or specific titrated dose).
Elderly
No specific dose adjustment for elderly patients is usually required unless there is significant renal or hepatic impairment. Start with lower doses and titrate slowly.
Renal_impairment
Use with caution in patients with renal impairment; dosage adjustment may be necessary. Monitor renal function.
How to Take
Take Dilock-TR 100 mg Capsule orally once daily, with or without food, preferably at the same time each day. Swallow the capsule whole; do not crush, chew, or divide it, as this may affect the extended-release properties.
Mechanism of Action
Diltiazem inhibits the influx of extracellular calcium ions across the membranes of myocardial and vascular smooth muscle cells. This action leads to peripheral vasodilation, reduced cardiac contractility, and slowed atrioventricular (AV) nodal conduction, resulting in decreased blood pressure and heart rate.
Pharmacokinetics
Onset
Onset of action for extended-release formulations is typically 2-3 hours.
Excretion
Excreted mainly in the urine (about 60-65%) as metabolites, with some excretion in feces.
Half life
Plasma elimination half-life is approximately 3.5-9 hours for extended-release preparations.
Absorption
Well absorbed from the GI tract, but undergoes extensive first-pass metabolism. Extended-release formulations provide sustained absorption over 12-24 hours.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Known hypersensitivity to diltiazem or any components of the formulation
- Sick sinus syndrome (unless a functional pacemaker is present)
- Second or third-degree AV block (unless a functional pacemaker is present)
- Severe hypotension (systolic blood pressure <90 mmHg)
- Acute myocardial infarction with pulmonary congestion
- Ventricular tachycardia (unless due to atrial fibrillation with an accessory pathway)
Drug Interactions
Digoxin
May increase serum digoxin levels, leading to toxicity.
Beta-blockers
Increased risk of bradycardia, AV block, and hypotension.
Statins (e.g., simvastatin, lovastatin)
Diltiazem may increase statin levels, increasing risk of myopathy.
CYP3A4 inducers (e.g., rifampin, phenytoin)
Can decrease diltiazem plasma concentrations.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Can increase diltiazem plasma concentrations.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe bradycardia, hypotension, first to third-degree AV block, and cardiac arrest. Management typically involves gastric lavage, activated charcoal, and supportive measures such as atropine for bradycardia, intravenous calcium gluconate, vasopressors for hypotension, and temporary cardiac pacing if necessary.
Pregnancy & Lactation
Pregnancy Category C. Diltiazem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Diltiazem is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Known hypersensitivity to diltiazem or any components of the formulation
- Sick sinus syndrome (unless a functional pacemaker is present)
- Second or third-degree AV block (unless a functional pacemaker is present)
- Severe hypotension (systolic blood pressure <90 mmHg)
- Acute myocardial infarction with pulmonary congestion
- Ventricular tachycardia (unless due to atrial fibrillation with an accessory pathway)
Drug Interactions
Digoxin
May increase serum digoxin levels, leading to toxicity.
Beta-blockers
Increased risk of bradycardia, AV block, and hypotension.
Statins (e.g., simvastatin, lovastatin)
Diltiazem may increase statin levels, increasing risk of myopathy.
CYP3A4 inducers (e.g., rifampin, phenytoin)
Can decrease diltiazem plasma concentrations.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Can increase diltiazem plasma concentrations.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe bradycardia, hypotension, first to third-degree AV block, and cardiac arrest. Management typically involves gastric lavage, activated charcoal, and supportive measures such as atropine for bradycardia, intravenous calcium gluconate, vasopressors for hypotension, and temporary cardiac pacing if necessary.
Pregnancy & Lactation
Pregnancy Category C. Diltiazem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Diltiazem is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture (refer to the specific product packaging for exact date).
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic, patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of diltiazem for its approved indications, including hypertension and angina management. Studies often focus on the sustained-release formulations for once-daily dosing.
Lab Monitoring
- Blood pressure and heart rate monitoring regularly
- Electrocardiogram (ECG) for heart rhythm and AV block
- Liver function tests (LFTs) periodically, especially in patients with hepatic impairment
Doctor Notes
- Emphasize slow titration of Diltiazem dosage to achieve optimal therapeutic effect with minimal side effects.
- Counsel patients on potential drug interactions, especially with beta-blockers and CYP3A4 inhibitors.
- Caution in patients with hepatic or renal impairment; monitor organ function closely.
- Advise patients not to abruptly discontinue the medication due to risk of rebound effects.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not crush, chew, or divide the capsule; swallow it whole.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Monitor your blood pressure and heart rate as advised by your healthcare provider.
- Inform your doctor about any new or worsening side effects.
Missed Dose Advice
If you miss a dose of Dilock-TR, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Driving Precautions
Diltiazem may cause dizziness or lightheadedness, especially at the start of treatment or when changing doses. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as recommended by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress through relaxation techniques.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.