Dilyt
Generic Name
Dicyclomine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dilyt 15 mg syrup | ৳ 40.13 | N/A |
Description
Overview of the medicine
Dilyt 15 mg syrup contains Dicyclomine Hydrochloride, an antispasmodic agent used to relieve smooth muscle spasms of the gastrointestinal tract, often associated with conditions like irritable bowel syndrome (IBS) or functional bowel disorders.
Uses & Indications
Dosage
Adults
Initially 10-20 mg (approx. 3.3-6.6 ml) three to four times a day. May be increased to 40 mg (approx. 13.3 ml) three to four times a day if needed. For 15mg/5ml strength, typically 5-10 ml (15-30 mg) three to four times daily.
Elderly
Start with lower doses and titrate based on response and tolerability due to increased sensitivity to anticholinergic effects.
Renal_impairment
Use with caution; consider reduced dosage due to potential for accumulation.
How to Take
Oral, usually taken before meals. Can be taken with food if stomach upset occurs.
Mechanism of Action
Dicyclomine is an anticholinergic (antimuscarinic) agent that blocks the action of acetylcholine at muscarinic receptors on smooth muscles, glands, and the central nervous system. This causes relaxation of smooth muscles, especially in the GI tract, and reduces spasm and pain.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily renal (urine), some fecal
Half life
1.8 hours (terminal half-life)
Absorption
Well absorbed orally
Metabolism
Extensively metabolized in the liver
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Glaucoma (angle-closure)
- Myasthenia gravis
- Obstructive uropathy
- Obstructive disease of the gastrointestinal tract (e.g., paralytic ileus, severe ulcerative colitis, toxic megacolon)
- Infants < 6 months
- Lactating women
Drug Interactions
Digoxin
Dicyclomine may increase digoxin levels.
Antacids
May decrease absorption of dicyclomine.
Phenothiazines
Increased risk of anticholinergic side effects.
Other anticholinergics
Increased risk of anticholinergic side effects.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include headache, nausea, vomiting, dizziness, dry mouth, blurred vision, dilated pupils, fever, hallucinations, convulsions. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Pregnancy: Category B (US FDA) – generally considered safe but use only if clearly needed. Consult doctor. Lactation: Contraindicated in nursing mothers due to potential for excretion in breast milk and adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Glaucoma (angle-closure)
- Myasthenia gravis
- Obstructive uropathy
- Obstructive disease of the gastrointestinal tract (e.g., paralytic ileus, severe ulcerative colitis, toxic megacolon)
- Infants < 6 months
- Lactating women
Drug Interactions
Digoxin
Dicyclomine may increase digoxin levels.
Antacids
May decrease absorption of dicyclomine.
Phenothiazines
Increased risk of anticholinergic side effects.
Other anticholinergics
Increased risk of anticholinergic side effects.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include headache, nausea, vomiting, dizziness, dry mouth, blurred vision, dilated pupils, fever, hallucinations, convulsions. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment. Physostigmine may be used in severe cases.
Pregnancy & Lactation
Pregnancy: Category B (US FDA) – generally considered safe but use only if clearly needed. Consult doctor. Lactation: Contraindicated in nursing mothers due to potential for excretion in breast milk and adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Numerous trials have evaluated dicyclomine's efficacy in IBS and other functional GI disorders, supporting its use as an antispasmodic.
Lab Monitoring
- Generally not required for routine use. Monitor for response to treatment and side effects.
Doctor Notes
- Caution in prostatic hypertrophy.
- Monitor for signs of paralytic ileus.
- Advise patients about potential for CNS effects.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Avoid driving or operating machinery if you experience dizziness or blurred vision.
- Inform your doctor about all other medications you are taking.
- Drink plenty of water to relieve dry mouth.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or blurred vision; exercise caution when driving or operating machinery.
Lifestyle Advice
- Identify and avoid triggers for IBS or functional bowel disorders (e.g., certain foods, stress). Maintain a healthy diet and lifestyle.
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Global Brand Names
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