Dimenta
Generic Name
Memantine 5 mg tablet
Manufacturer
XYZ Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dimenta 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Dimenta 5 mg Tablet contains Memantine, which is used to treat moderate to severe Alzheimer's disease. It helps improve memory, awareness, and the ability to perform daily functions by reducing abnormal activity in the brain.
Uses & Indications
Dosage
Adults
Initial: 5 mg once daily, gradually increased by 5 mg per week to a target dose of 10 mg twice daily (20 mg/day total).
Elderly
Same as adults, with careful titration.
Renal_impairment
Moderate (CrCl 30-49 mL/min): Max 10 mg/day. Severe (CrCl 5-29 mL/min): Max 5 mg/day.
How to Take
Administer orally, with or without food. Tablets can be taken whole.
Mechanism of Action
Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It modulates the effects of glutamate, an excitatory neurotransmitter, preventing neuronal damage caused by excessive glutamate activity, while allowing normal physiological function.
Pharmacokinetics
Onset
Steady-state concentrations are reached within several days of dosing.
Excretion
Primarily renal, with approximately 48% excreted unchanged via urine. Excretion is pH dependent.
Half life
Approximately 60-80 hours.
Absorption
Well absorbed orally; absolute bioavailability of about 100%. Peak plasma concentration is reached in 3-7 hours.
Metabolism
Minimal hepatic metabolism. Approximately 48% of the administered dose is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to memantine or any component of the formulation.
Drug Interactions
Sodium bicarbonate and other urine alkalinizers
May decrease memantine excretion, leading to increased plasma levels and potential toxicity.
NMDA antagonists (e.g., amantadine, ketamine, dextromethorphan)
Co-administration may increase the frequency and severity of CNS adverse reactions.
Drugs eliminated by renal tubular secretion (e.g., cimetidine, ranitidine, quinidine)
May alter plasma levels of memantine or the co-administered drug.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include agitation, confusion, hallucinations, seizures, stupor, coma, and slow heart rate. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnant women only if the potential benefit justifies the potential risk to the fetus. It is unknown whether memantine is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check specific packaging)
Availability
Pharmacies
Approval Status
FDA/DGDA Approved
Patent Status
Generic available, patents expired
Clinical Trials
Memantine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of moderate to severe Alzheimer's disease. Studies have shown improvements in cognitive function and global clinical status.
Lab Monitoring
- No routine specific laboratory monitoring is generally required. Renal function may be monitored in patients with impairment.
Doctor Notes
- Emphasize the importance of gradual dose titration to minimize potential side effects.
- Monitor patients for cognitive changes, behavioral disturbances, and adverse effects, especially during initial titration.
- Advise caregivers on proper administration and adherence.
Patient Guidelines
- Take Dimenta regularly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Dimenta may cause dizziness or confusion. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Engage in cognitive stimulating activities and social interactions.
- Ensure adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.