Dinoges-EV
Generic Name
Dinoprostone
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dinoges ev 2 mg tablet | ৳ 1,680.00 | N/A |
Description
Overview of the medicine
Dinoges-EV contains Dinoprostone, a synthetic prostaglandin E2 (PGE2) analogue. It is used for cervical ripening and for the induction of labor in pregnant women at term.
Uses & Indications
Dosage
Adults
One 10 mg vaginal insert (containing 10 mg dinoprostone) placed high in the posterior fornix of the vagina. It should remain in place for up to 12 hours. Not more than one insert should be used within a 24-hour period.
Elderly
Not applicable, primarily used in reproductive-aged women.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment.
How to Take
For vaginal use only. Administered by a healthcare professional in a hospital setting. The insert is removed upon onset of active labor, before amniotomy, or after 12 hours.
Mechanism of Action
Dinoprostone stimulates uterine contractions and promotes cervical ripening by enhancing the breakdown of collagen and increasing the water content of the cervix. It mimics the natural prostaglandin E2, playing a crucial role in the initiation of labor.
Pharmacokinetics
Onset
Cervical ripening typically begins within a few hours; effective labor induction can take up to 24 hours.
Excretion
Metabolites are primarily excreted in the urine.
Half life
Rapidly metabolized locally and systemically. The systemic half-life of dinoprostone is very short, in the range of minutes.
Absorption
Dinoprostone is slowly and continuously released from the vaginal insert, leading to sustained local and systemic absorption. Peak plasma concentrations are reached within several hours.
Metabolism
Extensively metabolized primarily in the lungs, liver, and kidneys by 15-hydroxy-dinoprostone dehydrogenase.
Side Effects
Contraindications
- Hypersensitivity to dinoprostone or excipients.
- History of uterine surgery (e.g., Cesarean section, hysterotomy).
- Significant cephalopelvic disproportion.
- Fetal distress where delivery is not imminent.
- Unexplained vaginal bleeding during pregnancy.
- Multiple gestation.
- Grand multiparity (six or more previous term pregnancies).
- Unengaged fetal head.
Drug Interactions
Oxytocin
Concomitant use with oxytocic agents is not recommended. If oxytocin is required, wait at least 30-60 minutes after removal of the Dinoges-EV insert.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light and moisture.
Overdose
Overdose may lead to uterine hyperstimulation (excessive uterine contractions) with or without fetal distress. Management involves removal of the insert, fetal and uterine monitoring, and symptomatic treatment. Beta-adrenergic agents may be used to relax the uterus.
Pregnancy & Lactation
Dinoges-EV is used specifically for labor induction at term. It is not for use in early pregnancy. Caution advised if breastfeeding, as dinoprostone and its metabolites may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to dinoprostone or excipients.
- History of uterine surgery (e.g., Cesarean section, hysterotomy).
- Significant cephalopelvic disproportion.
- Fetal distress where delivery is not imminent.
- Unexplained vaginal bleeding during pregnancy.
- Multiple gestation.
- Grand multiparity (six or more previous term pregnancies).
- Unengaged fetal head.
Drug Interactions
Oxytocin
Concomitant use with oxytocic agents is not recommended. If oxytocin is required, wait at least 30-60 minutes after removal of the Dinoges-EV insert.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light and moisture.
Overdose
Overdose may lead to uterine hyperstimulation (excessive uterine contractions) with or without fetal distress. Management involves removal of the insert, fetal and uterine monitoring, and symptomatic treatment. Beta-adrenergic agents may be used to relax the uterus.
Pregnancy & Lactation
Dinoges-EV is used specifically for labor induction at term. It is not for use in early pregnancy. Caution advised if breastfeeding, as dinoprostone and its metabolites may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to manufacturer's packaging for exact date.
Availability
Hospitals, specialized pharmacies
Approval Status
Approved (Bangladesh DGDA)
Patent Status
Off-patent (Dinoprostone), brand specific protection may apply
WHO Essential Medicine
YesClinical Trials
Dinoprostone has been extensively studied in numerous clinical trials for its efficacy and safety in cervical ripening and labor induction.
Lab Monitoring
- Continuous fetal heart rate monitoring
- Monitoring of uterine contraction frequency and intensity
Doctor Notes
- Ensure continuous monitoring of both maternal and fetal status throughout the administration period.
- Carefully assess contraindications before use.
- Remove insert promptly in cases of uterine hyperstimulation or fetal distress.
Patient Guidelines
- This medication is for hospital use only and must be administered by trained healthcare professionals.
- Patients will be continuously monitored for uterine activity and fetal well-being.
- Report any unusual symptoms or discomfort immediately.
Missed Dose Advice
Not applicable as it is a single-dose, hospital-administered product for labor induction.
Driving Precautions
Not applicable as Dinoges-EV is administered in a hospital setting for labor induction.
Lifestyle Advice
- Not applicable as it is an acute hospital-administered treatment for labor induction.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Dinoges-EV Brand
Other medicines available under the same brand name
