Dinxi
Generic Name
Dinximol
Manufacturer
Global Pharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dinxi 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Dinxi 5 mg Tablet is a non-opioid analgesic primarily used for chronic neuropathic pain and certain types of persistent pain. It works by modulating neurotransmitter levels in the brain to reduce pain perception.
Uses & Indications
Dosage
Adults
Initial dose: 5 mg orally once daily. May be increased to 10 mg after 1-2 weeks based on response and tolerability.
Elderly
No specific dose adjustment required, but use with caution due to potential increased sensitivity to adverse effects.
Renal_impairment
For moderate to severe renal impairment (CrCl <30 mL/min), consider reducing the dose to 2.5 mg once daily or increasing the dosing interval.
How to Take
Take orally with or without food. Swallow the tablet whole; do not crush, chew, or break.
Mechanism of Action
Dinximol acts as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). By increasing the availability of serotonin and norepinephrine in the central nervous system, it helps to modulate descending pain pathways, thereby reducing the perception of pain.
Pharmacokinetics
Onset
Analgesic effects typically begin within 1-2 weeks of continuous treatment.
Excretion
Mainly excreted in urine as metabolites (approximately 70%), with a smaller portion excreted in feces.
Half life
Approximately 12-18 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 2-4 hours.
Metabolism
Primarily hepatic metabolism via CYP2D6 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to dinximol or any excipients
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI
- Uncontrolled narrow-angle glaucoma
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
Alcohol
Increased risk of sedation and hepatotoxicity.
Warfarin/Anticoagulants
Potential for increased bleeding risk.
SSRIs/SNRIs/Tricyclic Antidepressants
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, vomiting, tachycardia, and potentially serotonin syndrome. Management involves supportive care, gastric lavage, and monitoring vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as dinximol may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to dinximol or any excipients
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI
- Uncontrolled narrow-angle glaucoma
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
Alcohol
Increased risk of sedation and hepatotoxicity.
Warfarin/Anticoagulants
Potential for increased bleeding risk.
SSRIs/SNRIs/Tricyclic Antidepressants
Increased risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, nausea, vomiting, tachycardia, and potentially serotonin syndrome. Management involves supportive care, gastric lavage, and monitoring vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as dinximol may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Patented
Clinical Trials
Extensive Phase I, II, and III clinical trials demonstrated efficacy in chronic neuropathic pain with a favorable safety profile compared to placebo.
Lab Monitoring
- Liver function tests (baseline and periodically)
- Renal function tests (baseline and periodically)
Doctor Notes
- Counsel patients on potential delayed onset of action and the importance of adherence.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Advise gradual tapering when discontinuing treatment to avoid withdrawal symptoms.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly, as this may lead to withdrawal symptoms.
- Report any unusual mood changes or thoughts of self-harm to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to support overall well-being.
- Avoid alcohol consumption while on this medication.
- Practice stress-reduction techniques like meditation or yoga.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.