Dipicard Plus
Generic Name
Carvedilol + Hydrochlorothiazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dipicard plus 5 mg tablet | ৳ 6.00 | N/A |
Description
Overview of the medicine
Dipicard Plus is a combination medicine used to treat high blood pressure. It contains Carvedilol, a beta-blocker, and Hydrochlorothiazide, a diuretic, working together to relax blood vessels and remove excess fluid from the body.
Uses & Indications
Dosage
Adults
Usually 1 tablet once daily, adjusted based on response. Max 2 tablets daily.
Elderly
Initial dosage may be lower, titrated carefully.
Renal_impairment
Use with caution; dose adjustment may be necessary for severe impairment due to Hydrochlorothiazide.
How to Take
Take orally, with food to enhance absorption and reduce orthostatic effects of carvedilol. Take at the same time each day.
Mechanism of Action
Carvedilol is a non-selective beta-adrenergic blocker with alpha1-blocking activity. It reduces heart rate and myocardial contractility and causes vasodilation. Hydrochlorothiazide is a thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubules, leading to increased excretion of sodium, chloride, and water.
Pharmacokinetics
Onset
1-2 hours (Carvedilol), ~2 hours (Hydrochlorothiazide).
Excretion
Carvedilol is primarily excreted via bile/feces; Hydrochlorothiazide is primarily excreted renally.
Half life
6-10 hours (Carvedilol), 5.6-14.8 hours (Hydrochlorothiazide).
Absorption
Carvedilol is rapidly absorbed (approx. 25-35% bioavailability); Hydrochlorothiazide is variably absorbed (approx. 60-80%).
Metabolism
Carvedilol undergoes extensive hepatic metabolism (CYP2D6, 2C9); Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- Hypersensitivity to components or sulfonamides
- Severe bradycardia
- Cardiogenic shock
- Decompensated heart failure
- Severe hepatic impairment
- Anuria
Drug Interactions
NSAIDs
May reduce diuretic and antihypertensive effects
Digoxin
Increases digoxin and carvedilol levels
Lithium
Increases lithium toxicity (due to HCTZ)
Fluoxetine
Increases carvedilol levels
Rifampicin
Decreases carvedilol levels
Insulin/Oral hypoglycemics
May mask hypoglycemia symptoms and require dose adjustment
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe hypotension, bradycardia, cardiac insufficiency, cardiogenic shock, cardiac arrest, respiratory problems, bronchospasm, vomiting, impaired consciousness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary, due to potential fetal harm (HCTZ) and adverse effects on neonates (Carvedilol). Use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to components or sulfonamides
- Severe bradycardia
- Cardiogenic shock
- Decompensated heart failure
- Severe hepatic impairment
- Anuria
Drug Interactions
NSAIDs
May reduce diuretic and antihypertensive effects
Digoxin
Increases digoxin and carvedilol levels
Lithium
Increases lithium toxicity (due to HCTZ)
Fluoxetine
Increases carvedilol levels
Rifampicin
Decreases carvedilol levels
Insulin/Oral hypoglycemics
May mask hypoglycemia symptoms and require dose adjustment
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe hypotension, bradycardia, cardiac insufficiency, cardiogenic shock, cardiac arrest, respiratory problems, bronchospasm, vomiting, impaired consciousness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary, due to potential fetal harm (HCTZ) and adverse effects on neonates (Carvedilol). Use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Various clinical trials have established the efficacy and safety of carvedilol and hydrochlorothiazide in treating hypertension.
Lab Monitoring
- Monitor blood pressure regularly
- Monitor kidney function (creatinine, BUN)
- Monitor electrolyte levels (potassium, sodium)
- Monitor liver function tests
- Monitor blood glucose in diabetic patients
Doctor Notes
- Advise patients not to interrupt therapy abruptly.
- Monitor electrolytes, renal function, and blood pressure regularly.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Avoid driving or operating machinery if you experience dizziness.
- Report any unusual side effects to your doctor.
- Maintain a healthy lifestyle, including diet and exercise.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or fatigue, especially at the start of treatment or when changing dosage. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Adopt a low-sodium diet.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Avoid smoking and excessive alcohol intake.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.