Disartan
Generic Name
disartan-5-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| disartan 5 mg tablet | ৳ 16.00 | ৳ 224.00 |
Description
Overview of the medicine
Disartan 5 mg Tablet contains Valsartan, an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure (hypertension), heart failure, and to reduce the risk of cardiovascular mortality in patients with left ventricular dysfunction after a myocardial infarction.
Uses & Indications
Dosage
Adults
Hypertension: Initial dose typically 80 mg once daily, maximum 320 mg/day. Heart Failure: Initial dose 40 mg twice daily, maximum 320 mg/day. Post-MI: Initial dose 20 mg twice daily, increasing to 40 mg twice daily within 7 days. The 5 mg strength is a very low dose and may be used for initial titration in very sensitive patients or specific pediatric populations, or in combination products. Always follow physician's prescription.
Elderly
No specific dose adjustment is required, but initiation with the lowest effective dose and careful titration is recommended due to potential increased sensitivity.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment or dialysis patients, caution is advised and a lower starting dose may be considered.
How to Take
Disartan 5 mg tablet is taken orally, typically once or twice daily, with or without food. It should be swallowed whole with water.
Mechanism of Action
Valsartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation, reduced systemic vascular resistance, and consequently, a decrease in blood pressure.
Pharmacokinetics
Onset
Onset of antihypertensive effect is typically within 2 hours, with maximal reduction usually achieved within 4-6 hours.
Excretion
Primarily excreted in feces (about 83% of the dose) and urine (about 13%) as unchanged drug.
Half life
The terminal elimination half-life is approximately 6-9 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring 2-4 hours after dosing. Absolute bioavailability averages about 23%. Food decreases the extent of absorption (AUC) by about 40% and peak plasma concentration (Cmax) by about 50%, but this is not clinically significant for efficacy.
Metabolism
Minimally metabolized; only about 20% of the dose is metabolized, primarily to a hydroxyl metabolite which is pharmacologically inactive. CYP450 enzymes are not significantly involved in valsartan metabolism.
Side Effects
Contraindications
- Pregnancy (due to fetal toxicity)
- Hypersensitivity to valsartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
- Severe hepatic impairment, biliary cirrhosis, or cholestasis
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels carefully.
Aliskiren
Contraindicated in diabetic patients and those with renal impairment (GFR <60 mL/min/1.73 m²) due to increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May attenuate the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics/Potassium supplements/Salt substitutes containing potassium
May lead to increased serum potassium (hyperkalemia).
Storage
Store in a cool, dry place below 30°C. Protect from moisture, heat, and direct light. Keep out of reach of children.
Overdose
The most likely manifestation of overdose would be hypotension with possible dizziness and syncope. Treatment should be symptomatic and supportive, including monitoring vital signs and cardiovascular status. Valsartan is not effectively removed by hemodialysis.
Pregnancy & Lactation
Disartan is contraindicated during pregnancy due to the risk of fetal injury and death. It is not recommended during lactation as it is unknown whether valsartan is excreted in human milk.
Side Effects
Contraindications
- Pregnancy (due to fetal toxicity)
- Hypersensitivity to valsartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
- Severe hepatic impairment, biliary cirrhosis, or cholestasis
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels carefully.
Aliskiren
Contraindicated in diabetic patients and those with renal impairment (GFR <60 mL/min/1.73 m²) due to increased risk of hyperkalemia, hypotension, and renal impairment.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May attenuate the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics/Potassium supplements/Salt substitutes containing potassium
May lead to increased serum potassium (hyperkalemia).
Storage
Store in a cool, dry place below 30°C. Protect from moisture, heat, and direct light. Keep out of reach of children.
Overdose
The most likely manifestation of overdose would be hypotension with possible dizziness and syncope. Treatment should be symptomatic and supportive, including monitoring vital signs and cardiovascular status. Valsartan is not effectively removed by hemodialysis.
Pregnancy & Lactation
Disartan is contraindicated during pregnancy due to the risk of fetal injury and death. It is not recommended during lactation as it is unknown whether valsartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic; Patent expired
Clinical Trials
Key clinical trials for Valsartan include the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial for hypertension, the Valsartan in Acute Myocardial Infarction (VALIANT) trial, and the Valsartan Heart Failure Trial (Val-HeFT).
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or those on potassium-sparing diuretics)
- Renal function tests (creatinine, BUN)
- Liver function tests (periodically if concerns arise)
Doctor Notes
- Always assess renal function and serum potassium levels before initiating valsartan and periodically thereafter, especially in at-risk patients.
- Counsel patients on the importance of regular blood pressure monitoring and adherence to treatment, even if asymptomatic.
- Strongly advise female patients of childbearing potential to use effective contraception due to significant fetal risk.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor, even if you feel well.
- Do not stop taking Disartan without consulting your doctor, as this may lead to a sudden increase in blood pressure.
- Monitor your blood pressure regularly at home and keep a record.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual side effects, especially swelling of the face, lips, tongue, or throat (angioedema).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Disartan may cause dizziness or fatigue. Patients should be cautioned about driving or operating machinery until they know how Disartan affects them.
Lifestyle Advice
- Adopt a low-sodium diet and limit processed foods.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy weight.
- Avoid smoking and limit alcohol consumption.
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