Ditrolac
Generic Name
Ketorolac Tromethamine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ditrolac 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ditrolac is a non-steroidal anti-inflammatory drug (NSAID) containing Ketorolac Tromethamine. It is primarily used for the short-term management of moderate to severe acute pain. It works by reducing hormones that cause inflammation and pain in the body.
Uses & Indications
Dosage
Adults
10 mg every 4-6 hours as needed, not to exceed 40 mg/day. Treatment duration should not exceed 5 days.
Elderly
Lower doses may be required; dosage should be adjusted based on renal function.
Renal_impairment
Contraindicated in patients with moderate to severe renal impairment. For mild impairment, use reduced dose and monitor renal function.
How to Take
Oral tablets should be swallowed whole with water, preferably with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by irreversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. This reduces the formation of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30 minutes after oral administration.
Excretion
Primarily renal (approximately 90% as metabolites and unchanged drug), with some fecal excretion.
Half life
Approximately 4-6 hours.
Absorption
Rapidly and completely absorbed orally. Peak plasma concentrations reached within 30-60 minutes after oral administration.
Metabolism
Primarily hepatic, mainly via hydroxylation and conjugation.
Side Effects
Contraindications
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Severe renal impairment
- Hypersensitivity to ketorolac or other NSAIDs
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Coronary Artery Bypass Graft (CABG) surgery
- Concomitant use with other NSAIDs, aspirin, or anticoagulants
- Pregnancy and lactation
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of GI adverse events.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors
Reduced efficacy of diuretics and ACE inhibitors, potential for renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy. Management involves symptomatic and supportive care, gastric lavage if recent ingestion, and close monitoring of renal function. Hemodialysis is not likely to be effective.
Pregnancy & Lactation
Contraindicated during pregnancy, especially in the third trimester due to risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Avoid during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Severe renal impairment
- Hypersensitivity to ketorolac or other NSAIDs
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Coronary Artery Bypass Graft (CABG) surgery
- Concomitant use with other NSAIDs, aspirin, or anticoagulants
- Pregnancy and lactation
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of GI adverse events.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors
Reduced efficacy of diuretics and ACE inhibitors, potential for renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy. Management involves symptomatic and supportive care, gastric lavage if recent ingestion, and close monitoring of renal function. Hemodialysis is not likely to be effective.
Pregnancy & Lactation
Contraindicated during pregnancy, especially in the third trimester due to risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Avoid during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Pharmacies, Hospitals
Approval Status
Approved (Bangladesh DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Ketorolac's efficacy in managing acute pain. Early trials focused on its analgesic potency compared to opioids and other NSAIDs.
Lab Monitoring
- Renal function (BUN, creatinine)
- Liver function tests (ALT, AST)
- Complete blood count (CBC)
- Stool for occult blood (for long-term use)
Doctor Notes
- Emphasize short-term use only (maximum 5 days) due to significant risks.
- Carefully assess GI and CV risk factors before prescribing.
- Monitor renal function, especially in elderly or renally impaired patients.
Patient Guidelines
- Do not exceed the recommended dose or duration of treatment (maximum 5 days).
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, vomiting blood) immediately.
- Avoid taking with other NSAIDs or aspirin.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it can increase the risk of stomach problems.
- Stay hydrated.
- Do not smoke.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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